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In vitro toxicity evaluation of single walled carbon nanotubes on human A549 lung cells.
The SWCNT were found to interfere with a number of the dyes used in the cytotoxicity assessment and the authors are currently conducting a comprehensive spectroscopic study to further investigate these interactions. Expand
A new approach to the toxicity testing of carbon-based nanomaterials--the clonogenic assay.
All three particle types were highly effective in inhibiting cell proliferation in all three cell lines, whereas only HaCaT and BEAS-2B cells also showed decreased cell viability. Expand
Spectroscopic analysis confirms the interactions between single walled carbon nanotubes and various dyes commonly used to assess cytotoxicity
The cytotoxicity of single walled carbon nanotubes was evaluated in the A549 human alveolar carcinoma cell line. Cell viability was assessed using the following indicator dyes, Commassie Blue, AlamarExpand
Resonant Mie scattering (RMieS) correction of infrared spectra from highly scattering biological samples.
In this paper a preliminary algorithm for correcting RMieS is presented and evaluated using simulated data and results show that the 'dispersion artefact' appears to be removed; however, the correction is not perfect. Expand
Reactive oxygen species (ROS) induced cytokine production and cytotoxicity of PAMAM dendrimers in J774A.1 cells.
The intracellular ROS generation and cytokine production induced cytotoxicity point towards the mechanistic pathway of cell death upon exposure to PAMAM dendrimers. Expand
SWCNT suppress inflammatory mediator responses in human lung epithelium in vitro.
The results of this study showed that HiPco SWCNT samples suppress inflammatory responses of A549 and NHBE cells, and this was also true for TNF-alpha stimulated cells. Expand
Single walled carbon nanotubes induce indirect cytotoxicity by medium depletion in A549 lung cells.
It is demonstrated that single walled carbon nanotubes can induce an indirect cytotoxic effect by alteration of cell culture medium (in which they have previously been dispersed) which potentially results in a false positive toxic effect being observed in cytotoxicity studies. Expand
Ecotoxicological assessment of silica and polystyrene nanoparticles assessed by a multitrophic test battery.
The cytotoxicity studies were found not to be a reliable ecotoxicity test model as agglomeration and sedimentation of the nanoparticles was observed at these concentrations, but the effects observed were dependent in some cases on the NP size, a higher effect being observed for the larger NPs. Expand
Resonant Mie scattering in infrared spectroscopy of biological materials--understanding the 'dispersion artefact'.
Infrared spectroscopic cytology is potentially a powerful clinical tool. However, in order for it to be successful, practitioners must be able to extract reliably a pure absorption spectrum from aExpand
Dispersion medium modulates oxidative stress response of human lung epithelial cells upon exposure to carbon nanomaterial samples.
It could be illustrated that in vitro exposure of lung epithelial cells to carbon nanomaterial samples results only in moderate or low oxidative stress under the exposure conditions employed, however, cell responses are strongly dependent on the vehicle used for dispersion. Expand