H. Bussey

Publications164
h-index67
Citations30,770
Highly Influential Citations1,692
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Functional profiling of the Saccharomyces cerevisiae genome
TLDR
It is shown that previously known and new genes are necessary for optimal growth under six well-studied conditions: high salt, sorbitol, galactose, pH 8, minimal medium and nystatin treatment, and less than 7% of genes that exhibit a significant increase in messenger RNA expression are also required for optimal Growth in four of the tested conditions.
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Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis.
TLDR
A total of 6925 Saccharomyces cerevisiae strains were constructed, by a high-throughput strategy, each with a precise deletion of one of 2026 ORFs (more than one-third of the ORFs in the genome), finding that 17 percent were essential for viability in rich medium.
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The Genetic Landscape of a Cell
TLDR
A network based on genetic interaction profiles reveals a functional map of the cell in which genes of similar biological processes cluster together in coherent subsets, and highly correlated profiles delineate specific pathways to define gene function.
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Systematic Genetic Analysis with Ordered Arrays of Yeast Deletion Mutants
TLDR
A method for systematic construction of double mutants, termed synthetic genetic array (SGA) analysis, in which a query mutation is crossed to an array of ∼4700 deletion mutants is developed, which should produce a global map of gene function.
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Life with 6000 Genes
TLDR
The genome of the yeast Saccharomyces cerevisiae has been completely sequenced through a worldwide collaboration and provides information about the higher order organization of yeast's 16 chromosomes and allows some insight into their evolutionary history.
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Global Mapping of the Yeast Genetic Interaction Network
TLDR
Because digenic interactions are common in yeast, similar networks may underlie the complex genetics associated with inherited phenotypes in other organisms.
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An in Vivo Map of the Yeast Protein Interactome
TLDR
A genome-wide in vivo screen for protein-protein interactions in Saccharomyces cerevisiae by means of a protein-fragment complementation assay (PCA) identified 2770 interactions among 1124 endogenously expressed proteins, revealing a previously unexplored subspace of the yeast protein interactome.
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Saccharomyces cerevisiae Mid2p Is a Potential Cell Wall Stress Sensor and Upstream Activator of thePKC1-MPK1 Cell Integrity Pathway
TLDR
Data are consistent with a role for Mid2p in sensing cell wall stress and in activation of a response that includes both increased chitin synthesis and the Mpk1p mitogen-activated protein kinase cell integrity pathway.
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Cell Wall Assembly in Saccharomyces cerevisiae
  • G. Lesage, H. Bussey
  • Biology, Engineering
    Microbiology and Molecular Biology Reviews
  • 1 June 2006
TLDR
An area where functional genomics offers new insights into the integration of cell wall growth and morphogenesis with a polarized secretory system that is under cell cycle and cell type program controls is reviewed.
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Exploring genetic interactions and networks with yeast
TLDR
A comparative understanding of genetic-interaction networks promises insights into some long-standing genetic problems, such as the nature of quantitative traits and the basis of complex inherited disease.
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