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Nutritional programming of the metabolic syndrome
The primary markers of the metabolic syndrome are central obesity, insulin resistance and hypertension. In this review, we consider the effect of changes in maternal nutrition during critical windows… Expand
Maternal Undernutrition during Early to Midgestation Programs Tissue-Specific Alterations in the Expression of the Glucocorticoid Receptor, 11β-Hydroxysteroid Dehydrogenase Isoforms, and Type 1…
We have investigated the effects of maternal nutrient restriction in the sheep during the period of rapid placental growth (i.e. 28–77 days gestation; term = 147 days) on feto-placental growth and… Expand
Thermal imaging to assess age-related changes of skin temperature within the supraclavicular region co-locating with brown adipose tissue in healthy children.
OBJECTIVE To establish the feasibility of infrared thermal imaging as a reproducible, noninvasive method for assessing changes in skin temperature within the supraclavicular region in vivo. STUDY… Expand
Maternal endocrine adaptation throughout pregnancy to nutritional manipulation: consequences for maternal plasma leptin and cortisol and the programming of fetal adipose tissue development.
Maternal nutrient restriction at specific stages of gestation has differential effects on fetal development such that the offspring are programmed to be at increased risk of adult disease. We… Expand
Long-term effects of nutritional programming of the embryo and fetus: mechanisms and critical windows.
- M. Symonds, T. Stephenson, D. Gardner, H. Budge
- Biology, Medicine
- Reproduction, fertility, and development
The maternal nutritional and metabolic environment is critical in determining not only reproduction, but also long-term health and viability. In the present review, the effects of maternal… Expand
Adipose tissue and fetal programming
Adipose tissue function changes with development. In the newborn, brown adipose tissue (BAT) is essential for ensuring effective adaptation to the extrauterine environment, and its growth during… Expand
The developmental transition of ovine adipose tissue through early life
Hypothermia induced by cold exposure at birth is prevented in sheep by the rapid onset of non‐shivering thermogenesis in brown adipose tissue (BAT). Changes in adipose tissue composition in early… Expand
The Ontogeny of Brown Adipose Tissue.
There are three different types of adipose tissue (AT)-brown, white, and beige-that differ with stage of development, species, and anatomical location. Of these, brown AT (BAT) is the least abundant… Expand
Adult epicardial fat exhibits beige features.
- H. Sacks, J. Fain, +5 authors M. E. Symonds
- The Journal of clinical endocrinology and…
- 3 July 2013
CONTEXT Human epicardial fat has been designated previously as brown-like fat. The supraclavicular fat depot in man has been defined as beige coexistent with classical brown based on its gene… Expand
Effect of Maternal Nutrition on Brown Adipose Tissue and Its Prolactin Receptor Status in the Fetal Lamb
We investigated the influence of maternal nutritional enhancement during the second half of gestation on prolactin receptor (PRLR) abundance in fetal brown adipose tissue (BAT) and liver close to… Expand