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Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial
TLDR
Blood pressure was reduced by both treatments, but the effects of the amlodipine-based regimen were more pronounced, especially in the early period, which emphasise the importance of prompt blood-pressure control in hypertensive patients at high cardiovascular risk. Expand
Angiotensin II Suppression in Humans by the Orally Active Renin Inhibitor Aliskiren (SPP100): Comparison With Enalapril
TLDR
Aliskiren has the potential to become the first orally active renin inhibitor that provides a true alternative to ACE-inhibitors and Ang II receptor antagonists in therapy for hypertension and other cardiovascular and renal diseases. Expand
Endothelial function in chronic congestive heart failure.
TLDR
An impaired endothelium-dependent dilation of forearm resistance vessels in CHF is demonstrated, suggesting a reduced release of nitric oxide on stimulation, and the basal release of Nitric oxide from endot Helium of forearm Resistance vessels is preserved or may even be enhanced, and may play an important compensatory role in chronic CHF by antagonizing neurohumoral vasoconstrictor forces. Expand
Cardiovascular response, feeding behavior and locomotor activity in mice lacking the NPY Y1 receptor
TLDR
The results demonstrate the importance of NPY Y1 receptors in NPY-mediated cardiovascular response and in the regulation of body weight through central control of energy expenditure and are also indicative of a role for the Y1 receptor in the control of food intake. Expand
Influence of oscillatory and unidirectional flow environments on the expression of endothelin and nitric oxide synthase in cultured endothelial cells.
TLDR
It is shown that the combination of pressure and oscillatory shear Stress can downregulate ecNOS levels, as well as upregulate transient expression of ET-1, compared with unidirectional shear stress. Expand
Essential hypertension: renin and aldosterone, heart attack and stroke.
TLDR
Plasma renin activity emerges as a potential risk factor for patients with essential hypertension — useful for identifying etiologies, determining prognosis and applying therapy. Expand
Blood pressure dependent and independent effects of antihypertensive treatment on clinical events in the VALUE Trial
TLDR
Reaching blood pressure control by 6 months, independent of drug type, was associated with significant benefits for subsequent major outcomes; the blood pressure response after just 1 month of treatment predicted events and survival. Expand
Neuropeptide Y (NPY) potentiates phenylephrine-induced mitogen-activated protein kinase activation in primary cardiomyocytes via NPY Y5 receptors.
TLDR
Results suggest that NPY, via G(i) protein-coupled NPY Y5 receptors, could participate in the development of cardiac hypertrophy during chronic sympathetic stimulation by potentiating alpha-adrenergic signals. Expand
A Systematic Comparison of the Properties of Clinically Used Angiotensin II Type 1 Receptor Antagonists
TLDR
Although there is general consensus that a continuous receptor blockade over a 24-hour period is desirable, the clinical relevance of other pharmacological differences between individual ARBs remains to be assessed. Expand
Local pulse pressure and regression of arterial wall hypertrophy during long-term antihypertensive treatment.
TLDR
The regression of carotid artery wall hypertrophy during long-term antihypertensive treatment was dependent on the reduction in local PP rather than on the lowering of mean BP, and the effect of PP lowering on IMT reduction was observed at the site of an elastic artery but not at the sites of a muscular artery. Expand
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