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On The Use Of Negative Selection In An Artificial Immune System
It is suggested that the negative selection algorithm, which is at work in the natural system, might have been copied too closely and argued against the use of negative selection if space is finite and self comprises only a small fraction of the available space orif space is infinite.
Applications of multiphoton tomographs and femtosecond laser nanoprocessing microscopes in drug delivery research.
Multiphoton excitation characteristics of cellular fluorophores of human skin in vivo.
In high-resolution multiphoton images of different skin layers, clear trends were found for fluorophores like keratin, NAD(P)H, melanin as well as for the elastin and collagen networks.
Optical skin biopsies by clinical CARS and multiphoton fluorescence/SHG tomography
The ultimate challenge for early diagnostics is label-free high-resolution intratissue imaging without taking physical biopsies. A novel hybrid femtosecond laser tomograph provides in vivo optical…
Multipurpose nonlinear optical imaging system for in vivo and ex vivo multimodal histology
A flexible multipurpose nonlinear microscopic imaging system based on a femtosecond excitation source and a photonic crystal fiber with multiple miniaturized time-correlated single-photon counting detectors that perfectly matches the needs for the clinical investigation of human skin in vivo.
High‐throughput continuous flow femtosecond laser‐assisted cell optoporation and transfection
- H. Breunig, A. Uchugonova, A. Batista, K. König
- BiologyMicroscopy research and technique
- 1 December 2014
The femtosecond‐laser based nanoprocessing system for transient optical cell membrane poration enables a tremendous increase of cell throughput compared to previous nonflow approaches by treating millions of cells, although with only limited efficiency.
Translation of two-photon microscopy to the clinic: multimodal multiphoton CARS tomography of in vivo human skin
- K. König, H. Breunig, A. Batista, A. Schindele, M. Zieger, M. Kaatz
- Physics, MedicineJournal of Biomedical Optics
- 1 January 2020
Clinical multiphoton coherent anti-Stokes Raman spectroscopy (CARS) tomography based on two tunable ultrashort near-infrared laser beams for label-free in vivo multimodal skin imaging helps to realize rapid early diagnosis as well as treatment control.
Fluorescence lifetime imaging of skin cancer
Fluorescence intensity imaging and fluorescence lifetime imaging microscopy (FLIM) using two photon microscopy (TPM) have been used to study tissue autofluorescence in ex vivo skin cancer samples. A…
Spectral characteristics of two-photon autofluorescence and second harmonic generation from human skin in vivo
The identification of the specific fluorophores is supported by analysis of additional in vivo fluorescence lifetime imaging and the possibility to investigate the penetration of nanoparticles from sunscreen lotion into skin in vivo is discussed.
The Complexity of Membership Problems for Circuits over Sets of Positive Numbers
- H. Breunig
- 27 August 2007
It is shown that the membership problem for the general case and for (∪∩,+,×) is PSPACE-complete, whereas it is NEXPTIME-hard if one allows 0, and several other cases are resolved.