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Innate Immune Defense of the Sponge Suberites domuncula against Bacteria Involves a MyD88-dependent Signaling Pathway
Data indicate that S. domuncula is provided with an innate immune system against Gram-negative bacteria; the ligand LPS (a pathogen-associated molecular pattern) is recognized by the pattern recognition receptor (LPS-interacting protein), which interacts with MyD88. Expand
Sustainable Production of Bioactive Compounds by Sponges—Cell Culture and Gene Cluster Approach: A Review
A 3D-aggregate primmorph culture system was established and it was proved that one bioactive compound, avarol/avarone, is produced by the sponge Dysidea avara, and another promising way to utilize the bioactive potential of the microorganisms is the cloning and heterologous expression of enzymes involved in secondary metabolism, such as the polyketide synthases. Expand
Thymine content of sea water as a measure of biosynthetic potential
A hydrolysis procedure along with a high-pressure liquid chromatographic procedure is given enabling simple and reliable thymine determinations in the nanogram range in different fractions ofExpand
Action of bleomycin on DNA and RNA.
Bleomycin affects thymidine-containing compounds such as DNA and polydeoxyribonucleotides by releasing free thymine and leaving aldehyde functions and possible reaction mechanisms are discussed. Expand
The quantitative determination of metabolites of 6-mercaptopurine in biological materials. I. A separation method for purine and 6-thiopurine bases and nucleosides using high-pressure liquid
  • H. Breter
  • Chemistry, Medicine
  • Analytical biochemistry
  • 15 May 1977
The most sensitive determination is achieved at 254 nm for common purines, at 291 nm for 6-methylthiopurines, on the base and (deoxy-)-ribonucleoside levels, and at 342 nm for6-thioguanines. Expand
Isolation and transcriptional characterization of three genes which function at start, the controlling event of the Saccharomyces cerevisiae cell division cycle: CDC36, CDC37, and CDC39.
The genes CDC36, CDC37, and CDC39, thought to function in the cell division control process in Saccharomyces cerevisiae, were isolated from a recombinant plasmid library prepared by partial digestionExpand
Oxygen-Controlled Bacterial Growth in the Sponge Suberites domuncula: toward a Molecular Understanding of the Symbiotic Relationships between Sponge and Bacteria
ABSTRACT Sponges (phylum Porifera), known to be the richest producers among the metazoans of bioactive secondary metabolites, are assumed to live in a symbiotic relationship with microorganisms,Expand
Phylogenetic relationship of the green alga Nanochlorum eukaryotum deduced from its chloroplast rRNA sequences
It is concluded that N.e. is most closely related to Chlorella vulgaris, and does not represent an early developed algal species; the primitive-appearing morphological and biochemical characteristics of N. e. Expand
The quantitative determination of metabolites of 6-mercaptopurine in biological materials. II. Advantages of a variable-wavelength HPLC spectrophotometric detector for the determination of
In the 291-355-nm range, common purines, which are normally contained in cell extracts as free bases, nucleosides and nucleotides exhibit only minute absorbances and so do not interfere in quantitative determinations of 6-thiopurine compounds. Expand