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BH3-only proteins: Orchestrators of apoptosis.
The BH3-only proteins of Bcl-2 family are essential initiators of apoptosis that propagate extrinsic and intrinsic cell death signals. The interaction of BH3-only proteins with other Bcl-2 familyExpand
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BH3‐in‐groove dimerization initiates and helix 9 dimerization expands Bax pore assembly in membranes
Pro‐apoptotic Bax induces mitochondrial outer membrane permeabilization (MOMP) by forming oligomers through a largely undefined process. Using site‐specific disulfide crosslinking,Expand
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A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection.
Aberrant apoptosis can lead to acute or chronic degenerative diseases. Mitochondrial outer membrane permeabilization (MOMP) triggered by the oligomerization of the Bcl-2 family proteins Bax/Bak is anExpand
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Molecular Pathways: Leveraging the BCL-2 Interactome to Kill Cancer Cells—Mitochondrial Outer Membrane Permeabilization and Beyond
The inhibition of apoptosis enables the survival and proliferation of tumors and contributes to resistance to conventional chemotherapy agents and is therefore a very promising avenue for theExpand
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Small molecules reveal an alternative mechanism of Bax activation
We identified five structurally different compounds that trigger the pro-apoptotic protein Bax to permeabilize mitochondrial outer membranes leading to cellular demise. The molecular mechanisms byExpand
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Pentachlorophenol removal from water using surfactant-enhanced filtration through low-pressure thin film composite membranes.
Removal of pentachlorophenol from water is investigated using the surfactant-enhanced cross-flow membrane filtration technique in which anionic surfactant; sodium dodecyl sulfate (SDS) is the carrierExpand
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The carboxyl-terminal sequence of Bim enables Bax activation and killing of unprimed cells
The Bcl-2 family BH3 protein Bim promotes apoptosis at mitochondria by activating the pore forming proteins Bax and Bak and by inhibiting the anti-apoptotic proteins Bcl-XL, Bcl-2 and Mcl-1. BimExpand
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