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Neuropathological stageing of Alzheimer-related changes
The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations, permitting the differentiation of six stages.
Staging of brain pathology related to sporadic Parkinson’s disease
Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry
- H. Braak, I. Alafuzoff, T. Arzberger, H. Kretzschmar, K. Del Tredici
- BiologyActa Neuropathologica
- 12 August 2006
To better meet the demands of routine laboratories this procedure is revised here by adapting tissue selection and processing to the needs of paraffin-embedded sections and by introducing a robust immunoreaction (AT8) for hyperphosphorylated tau protein that can be processed on an automated basis.
Stages in the development of Parkinson’s disease-related pathology
- H. Braak, E. Ghebremedhin, U. Rüb, H. Bratzke, K. Tredici
- Biology, PsychologyCell and Tissue Research
- 24 August 2004
The synucleinopathy, idiopathic Parkinson's disease, is a multisystem disorder that involves only a few predisposed nerve cell types in specific regions of the human nervous system that manifests itself in all of its clinical dimensions.
Staging of alzheimer's disease-related neurofibrillary changes
Phases of Aβ-deposition in the human brain and its relevance for the development of AD
Aβ-deposition in the entire brain follows a distinct sequence in which the regions are hierarchically involved and expands anterogradely into regions that receive neuronal projections from regions already exhibiting Aβ.
Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen
The here hypothesized mechanism offers one possible explanation for the sequential and apparently uninterrupted manner in which vulnerable brain regions, subcortical grays and cortical areas become involved in idiopathic Parkinson's disease.
Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years
- H. Braak, D. Thal, E. Ghebremedhin, K. Del Tredici
- Biology, MedicineJournal of Neuropathology and Experimental…
- 1 November 2011
The data suggest that tauopathy associated with sporadic Alzheimer disease may begin earlier than previously thought and possibly in the lower brainstem rather than in the transentorhinal region.
Gastric α-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology
Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease.
The data suggest that many patients with 'idiopathic' RBD are actually exhibiting an early clinical manifestation of an evolving neurodegenerative disorder, and may be appropriate for future drug therapies that affect synuclein pathophysiology, in which the development of parkinsonism and/or dementia could be delayed or prevented.