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Neuropathological stageing of Alzheimer-related changes
TLDR
The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations, permitting the differentiation of six stages. Expand
Staging of brain pathology related to sporadic Parkinson’s disease
TLDR
This study traces the course of the pathology in incidental and symptomatic Parkinson cases proposing a staging procedure based upon the readily recognizable topographical extent of the lesions. Expand
Stages in the development of Parkinson’s disease-related pathology
TLDR
The synucleinopathy, idiopathic Parkinson's disease, is a multisystem disorder that involves only a few predisposed nerve cell types in specific regions of the human nervous system that manifests itself in all of its clinical dimensions. Expand
Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry
TLDR
To better meet the demands of routine laboratories this procedure is revised here by adapting tissue selection and processing to the needs of paraffin-embedded sections and by introducing a robust immunoreaction (AT8) for hyperphosphorylated tau protein that can be processed on an automated basis. Expand
Staging of alzheimer's disease-related neurofibrillary changes
TLDR
Specific immunocytochemical methods (AT8) permit evaluation of neuronal changes well before the actual formation of neurofibrillary tangles and neuropil threads, which facilitates recognition of even subtle pathologic changes throughout the entire extent of cortical territories such as the transentorhinal and entorHinal regions. Expand
Phases of Aβ-deposition in the human brain and its relevance for the development of AD
TLDR
Aβ-deposition in the entire brain follows a distinct sequence in which the regions are hierarchically involved and expands anterogradely into regions that receive neuronal projections from regions already exhibiting Aβ. Expand
Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen
TLDR
The here hypothesized mechanism offers one possible explanation for the sequential and apparently uninterrupted manner in which vulnerable brain regions, subcortical grays and cortical areas become involved in idiopathic Parkinson's disease. Expand
Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years
TLDR
The data suggest that tauopathy associated with sporadic Alzheimer disease may begin earlier than previously thought and possibly in the lower brainstem rather than in the transentorhinal region. Expand
Gastric α-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology
TLDR
Investigation of the gastric myenteric and submucosal plexuses in 150 microm cryosections and 8 microm paraffin sections from five autopsy individuals found alpha-synuclein immunoreactive inclusions were found in neurons of the subMucosal Meissner plexus, whose axons could provide the first link in an uninterrupted series of susceptible neurons that extend from the enteric to the central nervous system. Expand
Where Does Parkinson Disease Pathology Begin in the Brain?
TLDR
The results of this semi-quantitative study of 30 autopsy cases with incidental Lewy body pathology indicate that PD in the brain commences with the formation of the very first immunoreactive Lewy neurites and Lewy bodies in non-catecholaminergic neurons of the dorsal glossopharyngeus-vagus complex. Expand
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