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Two phases of intracortical inhibition revealed by transcranial magnetic threshold tracking
- R. Fisher, Y. Nakamura, S. Bestmann, J. Rothwell, H. Bostock
- Biology, PsychologyExperimental Brain Research
- 25 January 2002
There are two distinct phases of inhibition, occurring at ISI=1 ms and ISI= 2.5 ms, differing both in thresholds and susceptibility to voluntary activity.
Threshold tracking techniques in the study of human peripheral nerve
Threshold measurements seem well suited for studies of metabolic and toxic neuropathies but insensitive to demyelination, until suitable equipment becomes more widely available, their full potential is unlikely to be realized.
Multiple measures of axonal excitability: A new approach in clinical testing
A new method is described that enables several measurements to be made on a motor nerve quickly and reproducibly, with minimal operator intervention, and makes it appropriate for routine clinical use.
Latent addition in motor and sensory fibres of human peripheral nerve.
The differences in latent addition between motor and sensory fibres are primarily due to differences in non‐classical, voltage‐dependent ion channels, active close to the resting potential, which may help to account for the longer strength‐duration time constant of sensory fibre, for their lower rheobase, and for their greater tendency to fire repetitively.
Effects of membrane polarization and ischaemia on the excitability properties of human motor axons.
Results should enable multiple excitability measurements to be used as a tool to identify changes in axonal membrane potential in neuropathy.
Excitability of human axons
Action potentials and membrane currents in the human node of Ranvier
Action potentials and membrane currents were recorded in single human myelinated nerve fibres under current- and voltage-clamp conditions at room temperature and a mathematical model based on the Frankenhaeuser-Huxley equations was derived.
Function and distribution of three types of rectifying channel in rat spinal root myelinated axons.
It was deduced that the inward rectification is a property of the internodal axon, that the slow outward rectifier is present at the nodes, and probably the internodes as well, and that the 4AP‐sensitive channels have a minor nodal and a majorInternodal representation.
KCNQ channels mediate IKs, a slow K+ current regulating excitability in the rat node of Ranvier
The nodal IKs current is mediated by KCNQ channels, which in large fibres of rat sciatic nerve appear to beKCNQ2 homomers, which is concluded to be the main contributor to nerve excitability in the rat.
Activity‐dependent excitability changes in normal and demyelinated rat spinal root axons.
The post‐tetanic depression that can follow continuous trains of impulses was attributed to the combination of increased threshold and enhanced superexcitable period due to hyperpolarization, not due to a membrane depolarization induced by extracellular potassium accumulation.