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New metabolites of di(2-ethylhexyl)phthalate (DEHP) in human urine and serum after single oral doses of deuterium-labelled DEHP
Most of the orally administered DEHP is systemically absorbed and excreted in urine, and there are strong hints that the secondary oxidised DEHP metabolites—not DEHP or MEHP—are the ultimate developmental toxicants.
Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism.
Characterization of the GSTT1 polymorphism will enable a more accurate assessment of human health risk from synthetic halomethanes and other industrial chemicals.
Di(2-ethylhexyl)phthalate (DEHP) metabolites in human urine and serum after a single oral dose of deuterium-labelled DEHP
Human metabolism of di(2-ethylhexyl)phthalate (DEHP) was studied after a single oral dose of 48.1 mg to a male volunteer. To avoid interference by background exposure the D4-ring-labelled DEHP…
Relevance of the deletion polymorphisms of the glutathione S-transferases GSTT1 and GSTM1 in pharmacology and toxicology.
Several lines of evidence suggest that hGGSTT1-1 and/or hGSTM1- 1 play a role in the deactivation of reactive oxygen species that are likely to be involved in cellular processes of inflammation, ageing and degenerative diseases.
Intravenous exposure to di(2-ethylhexyl)phthalate (DEHP): metabolites of DEHP in urine after a voluntary platelet donation
- H. Koch, H. Bolt, R. Preuss, R. Eckstein, V. Weisbach, J. Angerer
- Medicine, BiologyArchives of Toxicology
- 30 July 2005
Toxicological endpoints observed for DEHP after oral application should be considered relevant for medical procedures causing intravenous DEHP exposure, like apheresis procedures, and especially women in their reproductive age need to be protected from DEHP exposures exceeding the preventive limit values.
The cytochrome P-450 isoenzyme CYP2E1 in the biological processing of industrial chemicals: consequences for occupational and environmental medicine
Available studies indicate a wide variation in human CYP2E1 expression, which is very likely based on complex gene–environment interactions, which are related to individual expressions of clinical symptoms of chemical toxicity, to results of biological monitoring of exposed workers, and to the interpretation of results of epidemiological or molecular-epidemiological studies.
Head and Neck Squamous-Cell Cancer and its Association with Polymorphic Enzymes of Xenobiotic Metabolism and Repair
- V. Harth, Martin Schäfer, K. Ickstadt
- BiologyJournal of Toxicology and Environmental Health…
- 3 June 2008
To investigate the role of genetically determined individual predispositions in enzymes of xenobiotic metabolism and in repair enzymes under the exogenous risk factor tobacco smoke in the carcinogenesis of HNSCC, a case-control study on 312 cases and 300 noncancer controls is conducted.
Excretion of mercapturic acids of acrylamide and glycidamide in human urine after single oral administration of deuterium-labelled acrylamide
The metabolic fate of AA in humans was more similar to that in rats than in mice as already demonstrated in terms of the haemoglobin adducts, and a genotoxic potency of AA mediated by GA could be supposed to be comparable in rats and humans.
Breast cancer: a candidate gene approach across the estrogen metabolic pathway
The tested polymorphisms of the estrogen metabolic pathway may not play a direct role in breast cancer risk and future association studies should be extended to other polymorphisms and other regulatory pathways.
Endocrine disruptors: update on xenoestrogens
Consequences from previous clinical use of the potent estrogen diethyl- stilbestrol with particular emphasis on dose-response relationships, other observations in humans exposed to estrogenic chemicals in an occupational context, and available information on exposure levels of synthetic and naturally occurring estrogens in the diet are addressed.