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Chronic Pulmonary Artery Pressure Elevation Is Insufficient to Explain Right Heart Failure
Background— The most important determinant of longevity in pulmonary arterial hypertension is right ventricular (RV) function, but in contrast to experimental work elucidating the pathobiology ofExpand
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The monocrotaline model of pulmonary hypertension in perspective.
Severe forms of pulmonary arterial hypertension (PAH) are characterized by various degrees of remodeling of the pulmonary arterial vessels, which increases the pulmonary vascular resistance and rightExpand
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The technique of impedance cardiography.
Other than fluctuations caused by respiration thoracic tissue impedance is constant. Blood-related impedance changes repeat themselves with every heart beat and are linked to cardiac activity.
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Adrenergic receptor blockade reverses right heart remodeling and dysfunction in pulmonary hypertensive rats.
RATIONALE Most patients with pulmonary arterial hypertension (PAH) die from right heart failure. Beta-adrenergic receptor blockade reduces mortality by about 30% in patients with left-sided systolicExpand
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Endothelial-to-Mesenchymal Transition in Pulmonary Hypertension
Background— The vascular remodeling responsible for pulmonary arterial hypertension (PAH) involves predominantly the accumulation of &agr;-smooth muscle actin–expressing mesenchymal-like cells inExpand
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Pathobiology of pulmonary arterial hypertension and right ventricular failure
Pulmonary arterial hypertension (PAH) is no longer an orphan disease. There are three different classes of drugs for the treatment of PAH that are currently being used and an increasing number ofExpand
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The effects of exercise on right ventricular contractility and right ventricular-arterial coupling in pulmonary hypertension.
RATIONALE Exercise tolerance is decreased in patients with pulmonary hypertension (PH). It is unknown whether exercise intolerance in PH coincides with an impaired rest-to-exercise response in rightExpand
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Electric Cell-substrate Impedance Sensing for the Quantification of Endothelial Proliferation, Barrier Function, and Motility
Electric Cell-substrate Impedance Sensing (ECIS) is an in vitro impedance measuring system to quantify the behavior of cells within adherent cell layers. To this end, cells are grown in specialExpand
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Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using Tumor-Educated Platelets
Summary Blood-based liquid biopsies, including tumor-educated blood platelets (TEPs), have emerged as promising biomarker sources for non-invasive detection of cancer. Here we demonstrate thatExpand
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Suppression of histone deacetylases worsens right ventricular dysfunction after pulmonary artery banding in rats.
RATIONALE Inhibitors of histone deacetylases (HDACs) reduce pressure-overload-induced left ventricular hypertrophy and dysfunction, but their effects on right ventricular (RV) adaptation to pressureExpand
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