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Inducing and expanding regulatory T cell populations by foreign antigen
Evidence suggests that regulatory T cells expressing the transcription factor Foxp3 develop extrathymically and intrathymically. Mechanisms of extrathymic induction require further scrutiny,Expand
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Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes
The mechanism of self-tolerance is studied in T-cell-receptor transgenic mice expressing a receptor in many of their T cells for the male (H–Y) antigen in the context of class I H–2Db MHC antigens.Expand
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Origin of regulatory T cells with known specificity for antigen
T cell receptor agonists can induce the differentiation of regulatory T (TR) cells. We report here that the immunoglobulin κ–controlled expression of an agonist in different cell types correlatedExpand
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Foxp3 occupancy and regulation of key target genes during T-cell stimulation
Foxp3+CD4+CD25+ regulatory T (Treg) cells are essential for the prevention of autoimmunity. Treg cells have an attenuated cytokine response to T-cell receptor stimulation, and can suppress theExpand
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Mechanisms of suppression by suppressor T cells
Mechanisms of immunosuppression by CD4+CD25+ suppressor T cells have been addressed using many in vitro and in vivo conditions. However, those studies have not yielded a single mode of action. ThisExpand
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Efficient thymic immigration of B220+ lymphoid-restricted bone marrow cells with T precursor potential
Using a human CD25 reporter transgene controlled by regulatory sequences from the gene encoding pre-T cell receptor α, we identified a common lymphocyte precursor (CLP-2) population that, in contrastExpand
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Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia
The chromosomal translocation t(7;9) in human T-cell acute lymphoblastic leukaemia (T-ALL) results in deregulated expression of a truncated, activated form of Notch 1 (TAN1) under the control of theExpand
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Checkpoints in lymphocyte development and autoimmune disease
Antigen receptor–controlled checkpoints in B lymphocyte development are crucial for the prevention of autoimmune diseases such as systemic lupus erythematosus. Checkpoints at the stage of pre–B cellExpand
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Cyclin C is a haploinsufficient tumour suppressor
Cyclin C was cloned as a growth-promoting G1 cyclin, and was also shown to regulate gene transcription. Here we report that in vivo cyclin C acts as a haploinsufficient tumour suppressor, byExpand
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Positive selection of antigen-specific T cells in thymus by restricting MHC molecules
Thymus-derived lymphocytes (T cells) recognize antigen in the context of class I or class II molecules encoded by the major histocompatibility complex (MHC) by virtue of the heterodimeric αβ T-cellExpand
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