• Publications
  • Influence
Cellular and Network Mechanisms of Spike‐Wave Seizures
Summary:  Spike‐wave seizures are often considered a relatively “pure” form of epilepsy, with a uniform defect present in all patients and involvement of the whole brain homogenously. Here, weExpand
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Dynamic Time Course of Typical Childhood Absence Seizures: EEG, Behavior, and Functional Magnetic Resonance Imaging
Absence seizures are 5–10 s episodes of impaired consciousness accompanied by 3–4 Hz generalized spike-and-wave discharge on electroencephalography (EEG). The time course of functional magneticExpand
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Cerebral energetics and spiking frequency: The neurophysiological basis of fMRI
Functional MRI (fMRI) is widely assumed to measure neuronal activity, but no satisfactory mechanism for this linkage has been identified. Here we derived the changes in the energetic component fromExpand
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Impaired consciousness in epilepsy
  • H. Blumenfeld
  • Psychology, Medicine
  • The Lancet Neurology
  • 1 September 2012
Consciousness is essential to normal human life. In epileptic seizures consciousness is often transiently lost, which makes it impossible for the individual to experience or respond. These effectsExpand
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Consciousness and epilepsy: why are patients with absence seizures absent?
Epileptic seizures cause dynamic, reversible changes in brain function and are often associated with loss of consciousness. Of all seizure types, absence seizures lead to the most selective deficitsExpand
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Negative BOLD with large increases in neuronal activity.
Blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) is widely used in neuroscience to study brain activity. However, BOLD fMRI does not measure neuronal activity directlyExpand
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Positive and negative network correlations in temporal lobe epilepsy.
Temporal lobe seizures are accompanied by complex behavioral phenomena including loss of consciousness, dystonic movements and neuroendocrine changes. These phenomena may arise from extended neuralExpand
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Impaired attention and network connectivity in childhood absence epilepsy
Patients with childhood absence epilepsy (CAE) often demonstrate impaired interictal attention, even with control of their seizures. No previous study has investigated the brain networks involved inExpand
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Cortical and subcortical networks in human secondarily generalized tonic-clonic seizures.
Generalized tonic-clonic seizures are among the most dramatic physiological events in the nervous system. The brain regions involved during partial seizures with secondary generalization have notExpand
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From Molecules to Networks: Cortical/Subcortical Interactions in the Pathophysiology of Idiopathic Generalized Epilepsy
Summary: Generalized epilepsy involves abnormally synchronized activity in large‐scale neuronal networks. Burst firing of action potentials is a potent mechanism for increasing neural synchrony andExpand
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