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- Publications
- Influence
[Nonsedative H1 antihistaminics].
- Hana Blehová, Jan Metyš
- Medicine
- Casopis lekaru ceskych
- 24 May 1991
Recent research provided evidence that effective H1-antihistaminic drugs need not exert a central and sedative action. Non-sedative H1-antihistaminics can aptly replace older combined preparations of… Expand
[A comparative pharmacologic study of histamine H-1 antagonists].
- H. Blehová, J. Metyš, R. Soucek, M. Valchář
- Chemistry, Medicine
- Ceskoslovenska farmacie
- 1 April 1991
In a representative group of 10 conventional antihistaminic agents, a comparison of their H1-antagonistic efficacy was carried out in a series of pharmacological tests. A very good correlation of… Expand
[Pharmacologic profile of dithiadenoxide, a potential non-sedating H1-antihistaminic].
- H. Blehová, J. Metyš
- Chemistry, Medicine
- Ceskoslovenska farmacie
- 1 September 1992
Dithiadenoxide, a product of metabolic S-oxidation of the H1-antihistaminic agent dithiaden (bisulepin, Dithiaden), is also an effective histaminic H1-antagonist in pharmacological experiments in in… Expand
Potential antihistaminics: Tricyclic carboxylic acids derived from 6,11-dihydrodibenzo[ b,e ]thiepine and 4,9-dihydrothieno[2,3- c ]-2-benzothiepine
- K. Šindelář, J. Holoubek, E. Svátek, J. Metyš, H. Blehová, Z. Polívka
- Chemistry
- 1991
Reaction of nitrile IVa with the Grignard’s reagent 1-methyl-4-piperidylmagnesium chloride gave carbinol XIb as product. Carbinols XIa and XIb were dehydrated and hydrolysed with dilute hydrochloric… Expand