Expression cloning of GABAB receptors uncovers similarity to metabotropic glutamate receptors
- K. Kaupmann, K. Huggel, B. Bettler
- BiologyNature
- 20 March 1997
The cloning of GABAB receptors is reported and photoaffinity labelling experiments suggest that the cloned receptors correspond to two highly conserved GABAB receptor forms present in the vertebrate nervous system.
Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.
- K. Kaupmann, K. Huggel, B. Bettler
- BiologyNature
- 1997
The cloning of GABA(B) receptors is reported and photoaffinity labelling experiments suggest that the cloned receptors correspond to two highly conserved GABA( B) receptor forms present in the vertebrate nervous system.
Human gamma-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channels.
- K. Kaupmann, V. Schuler, B. Bettler
- BiologyProceedings of the National Academy of Sciences…
- 8 December 1998
The cloning and functional characterization of two human GABABRs are reported, and it is demonstrated that in transfected mammalian cells hR 1a and hR1b can modulate heteromeric Kir3.1/3.2 and Kir 3.4 channels, which supports the notion that Kir3 channels are the postsynaptic effectors of GABA BRs.
CGP 35348: a centrally active blocker of GABAB receptors.
- H. Olpe, G. Karlsson, H. Bittiger
- Biology, ChemistryEuropean Journal of Pharmacology
- 2 October 1990
Mutagenesis and Modeling of the GABAB Receptor Extracellular Domain Support a Venus Flytrap Mechanism for Ligand Binding*
- T. Galvez, M. Parmentier, J. Pin
- Biology, ChemistryJournal of Biological Chemistry
- 7 May 1999
A three-dimensional model of the LBP-like domain of the GABAB receptor was constructed based on the known structure of LBP and proposes that the initial step in the activation of the receptor by agonist results from the closure of the two lobes of the binding domain.
CGP 20712 A: a useful tool for quantitating β1- and β2-adrenoceptors
- D. Dooley, H. Bittiger, N. Reymann
- Biology, Chemistry
- 14 October 1986
Binding characteristics of γ-hydroxybutyric acid as a weak but selective GABAB receptor agonist
- P. Mathivet, R. Bernasconi, J. Barry, C. Marescaux, H. Bittiger
- Biology, Chemistry
- 19 February 1997
CGP 20712 A: a useful tool for quantitating beta 1- and beta 2-adrenoceptors.
- D. Dooley, H. Bittiger, N. Reymann
- BiologyEuropean Journal of Pharmacology
- 1986
CGP 20712 A is a useful tool for estimating percentages of beta 1- and beta 2-adrenoceptors in a given tissue and a distinct biphasic curve was evident for neocortical and cerebellum.
The actions of orally active GABAB receptor antagonists on GABAergic transmission in vivo and in vitro.
- H. Olpe, M. Steinmann, H. Bittiger
- BiologyEuropean Journal of Pharmacology
- 23 March 1993
Developmental Changes of Agonist Affinity at GABABR1 Receptor Variants in Rat Brain
- B. Malitschek, D. Rüegg, R. Kuhn
- BiologyMolecular and Cellular Neuroscience
- 1 September 1998
It is demonstrated that two N-terminal splice variants of the metabotropic receptor for GABA (gamma-amino-butyric acid) were cloned and are identical with GABAB receptors that are photoaffinity labeled with [125I]CGP71872 in rat brain.
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