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Active Suppression of the Pulmonary Immune Response by Francisella tularensis Schu41
TLDR
It is demonstrated that Schu4 actively suppressed in vivo responses to secondary stimuli (LPS), e.g., failure to recruit granulocytes/monocytes and stimulate resident DC, which may explain the increased virulence of type A strains compared with their more attenuated counterparts. Expand
Establishment of stable, cell-mediated immunity that makes "susceptible" mice resistant to Leishmania major.
TLDR
In the present study, "susceptible" mice injected with a small number of parasites mounted a cell-mediated response and acquired resistance to a larger, normally pathogenic, challenge and may be applicable in diseases in which protection is dependent on cell- mediated immunity. Expand
Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus
TLDR
The H5N1 virus was exceptional for the extent of tissue damage, cytokinemia, and interference with immune regulatory mechanisms, which may help explain the extreme virulence of HPAI viruses in humans. Expand
Multiple Immune Factors Are Involved in Controlling Acute and Chronic Chikungunya Virus Infection
TLDR
It is suggested that chronic arthritic disease is a consequence of persistent, replicating and transcriptionally active CHIKV RNA, and several factors are involved in virus control. Expand
Mitogenic activity and cytokine levels in non‐healing and healing chronic leg ulcers
TLDR
Results suggest that healing in chronic venous leg ulcers may be impaired by inflammatory mediators rather than inhibited by a deficiency of growth factors in these chronic wounds. Expand
Dengue viral infections; pathogenesis and epidemiology.
TLDR
A number of theories relating to the pathogenesis of dengue haemorrhagic fever exist that have evolved from the analysis of the epidemiology of this disease, but the exact mechanisms for the disease are unknown. Expand
Proteolysis of human hemoglobin by schistosome cathepsin D.
TLDR
The gastrodermal location, elevated expression in females, acidic pH optima, similar substrate preferences in two species, and the discrete substrate preferences compared with human cathepsin D together provide compelling support for the hypothesis that schistosomal cathep D plays an integral role in hemoglobin proteolysis, and might be selectively targeted by drugs based on protease inhibition. Expand
Molecular epidemiology of Blastocystis in pigs and their in-contact humans in Southeast Queensland, Australia, and Cambodia.
TLDR
It appears likely that pigs are natural hosts of Blastocystis with a high prevalence of ST5 that is presumably the pig-adapted ST in these regions, and close contact between pigs and their handlers may increase the risks of zoonotic transmission. Expand
Mid‐ to late term hypoxia in the mouse alters placental morphology, glucocorticoid regulatory pathways and nutrient transporters in a sex‐specific manner
TLDR
While maternal hypoxia increased maternal glucose and corticosterone levels in both sexes, placental adaptations to impaired maternal physiology were more evident in female fetuses, in which factors responsible for the regulation of glucocorticoids and nutrient transport were most severely affected by maternal Hypoxia. Expand
Diversity of Blastocystis subtypes in dogs in different geographical settings
TLDR
It appears that dogs are not natural hosts for Blastocystis but rather are transiently and opportunistically infected with a diversity of STs. Expand
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