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A neuromodulatory role of interleukin-1β in the hippocampus
It is shown for the first time that the production of biologically significant amounts of IL-1β in the brain can be induced by a sustained increase in the activity of a discrete population of neurons and a physiological involvement of this cytokine in synaptic plasticity is suggested. Expand
Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones.
The results strongly support the existence of an immunoregulatory feedback circuit in which IL-1 acts as an afferent and glucocorticoid as an efferent hormonal signal in which the pituitary-adrenal axis is stimulated. Expand
A neuromodulatory role of interleukin-1beta in the hippocampus.
- H. Schneider, F. Pitossi, D. Balschun, A. Wagner, A. del Rey, H. Besedovsky
- Proceedings of the National Academy of Sciences…
It is shown for the first time that the production of biologically significant amounts of IL-1beta in the brain can be induced by a sustained increase in the activity of a discrete population of neurons and suggest a physiological involvement of this cytokine in synaptic plasticity. Expand
Immune-neuro-endocrine interactions: facts and hypotheses.
At the beginning of the second half of the 20th century, most efforts were directed at understanding the molecular and cellular basis of the immune response and the mechanisms of acquisition of immunologic responses. Expand
Interleukin‐6: a cytokine to forget
- D. Balschun, W. Wetzel, +4 authors H. Besedovsky
- Medicine, Biology
- FASEB journal : official publication of the…
- 1 November 2004
Blockade of endogenous IL‐6 by application of a neutralizing anti‐IL6 antibody 90 min after tetanus caused a remarkable prolongation of LTP, and implicate IL‐ 6 in the mechanisms controlling the kinetics and amount of information storage. Expand
Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1.
- F. Berkenbosch, J. V. van Oers, A. del Rey, F. Tilders, H. Besedovsky
- Biology, Medicine
- 23 October 1987
The notion of the existence of an immunoregulatory feedback circuit between the immune system and the brain is supported by three lines of evidence. Expand
Microglial activation with atypical proinflammatory cytokine expression in a rat model of Parkinson's disease
- A. Depino, C. Earl, +5 authors W. Oertel
- Biology, Medicine
- The European journal of neuroscience
- 1 November 2003
The notion that chronic neuronal death per se does not induce secretion of these proinflammatory cytokines but that an additional stimulus is necessary to stimulate pro inflammatory cytokine production is supported. Expand
Chronic neuropathic pain-like behavior correlates with IL-1β expression and disrupts cytokine interactions in the hippocampus
It is proposed that neuropathic pain engages emotional learning, suggesting the involvement of the hippocampus, and alterations in cytokine expression are restricted to the hippocampus contralateral to the injury side, again implying that the observed changes reflect nociception. Expand
Induction of cytokine transcripts in the central nervous system and pituitary following peripheral administration of endotoxin to mice
- F. Pitossi, A. del Rey, A. Kabiersch, H. Besedovsky
- Biology, Medicine
- Journal of neuroscience research
- 15 May 1997
The capacity of brain cells to synthesize different cytokine mRNAs in vivo is shown and the kinetics of their expression in several brain areas and in the periphery in parallel to the activation of a neuroendocrine pathway by endotoxin is defined. Expand
Physiology of psychoneuroimmunology: A personal view
This article offers a personal view on how the concept of the existence of a network of immune-neuro-endocrine interactions has evolved in the last 30 years in relation to immunoregulation and brain functions. Expand