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A neuromodulatory role of interleukin-1β in the hippocampus
It is widely accepted that interleukin-1β (IL-1β), a cytokine produced not only by immune cells but also by glial cells and certain neurons influences brain functions during infectious andExpand
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  • Open Access
A neuromodulatory role of interleukin-1beta in the hippocampus.
It is widely accepted that interleukin-1beta (IL-1beta), a cytokine produced not only by immune cells but also by glial cells and certain neurons influences brain functions during infectious andExpand
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Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1.
Intraperitoneal administration of human recombinant interleukin-1 (IL-1) to rats can increase blood levels of corticosterone and adrenocorticotropic hormone (ACTH). The route by which IL-1 affectsExpand
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Network of immune-neuroendocrine interactions.
In order to bring the self-regulated immune system into conformity with other body systems its functioning within the context of an immune-neuroendocrine network is proposed. This hypothesis is basedExpand
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Physiology of psychoneuroimmunology: A personal view
This article offers a personal view on how the concept of the existence of a network of immune-neuro-endocrine interactions has evolved in the last 30 years. The main topic addressed is the relevanceExpand
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Cytokines as modulators of the hypothalamus-pituitary-adrenal axis
The hypothalamus-pituitary-adrenal (HPA) axis is stimulated during the course of certain immune, inflammatory and neoplastic processes. IL-1 is an important immunologically derived cytokine mediatingExpand
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Interleukin-1 induces changes in norepinephrine metabolism in the rat brain
Interleukin-1 (IL-1) is a hormone that, apart from playing a key role in immune and inflammatory processes, can also affect mechanisms under brain control. To gain a better understanding of theExpand
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Integrated evolutionary, immunological, and neuroendocrine framework for the pathogenesis of chronic disabling inflammatory diseases
The pathogenesis of chronic disabling inflammatory diseases (CDIDs) is poorly understood. Current concepts that focus on abnormalities of the immune system are, in our view, incomplete. Here weExpand
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Interleukin‐1 and Glucocorticoid Hormones Integrate an Immunoregulatory Feedback Circuit a
Among the homeostatic systems of an organism, the immune system has special relevance for restoring the physiological balance when challenged by modified self components and non-self stimuli. ItsExpand
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A cytokine network involving brain-borne IL-1β, IL-1ra, IL-18, IL-6, and TNFα operates during long-term potentiation and learning
We have previously shown that long-term potentiation (LTP) induces hippocampal IL-1β and IL-6 over-expression, and interfering their signalling either inhibits or supports, respectively, LTPExpand
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