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Excitotoxicity in the lung: N-methyl-D-aspartate-induced, nitric oxide-dependent, pulmonary edema is attenuated by vasoactive intestinal peptide and by inhibitors of poly(ADP-ribose) polymerase.
Excitatory amino acid toxicity, resulting from overactivation of N-methyl-D-aspartate (NMDA) glutamate receptors, is a major mechanism of neuronal cell death in acute and chronic neurologicalExpand
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Nitric oxide as a mediator of oxidant lung injury due to paraquat.
At low concentrations, nitric oxide is a physiological transmitter, but in excessive concentrations it may cause cell and tissue injury. We report that in acute oxidant injury induced by theExpand
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NMDA receptor activation: critical role in oxidant tissue injury.
The excitatory amino acid glutamate serves important neurologic functions, but overactivation of its N-methyl-D-aspartate (NMDA) receptor is toxic to neurons (excitotoxicity). We report that NMDAExpand
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Vasoactive intestinal peptide prevents lung injury due to xanthine/xanthine oxidase.
Reactive oxygen species mediate injury and inflammation in many tissues. The addition of xanthine and xanthine oxidase to perfused rat lungs led to increases in peak airway pressure and perfusionExpand
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N-methyl-d-aspartate receptors outside the central nervous system: Activation causes acute lung injury that is mediated by nitric oxide synthesis and prevented by vasoactive intestinal peptide
N-methyl-D-aspartate receptors, found throughout the mammalian brain, are a component of the major excitatory transmitter system. Strong evidence exists that N-methyl-D-aspartate receptors, byExpand
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New evidence for transmitter role of VIP in the airways: impaired relaxation by a catalytic antibody.
The identity of the transmitter(s) of nonadrenergic, noncholinergic airway smooth muscle relaxation has long been investigated. Recently, nitric oxide (NO) has been proposed as the main, if not theExpand
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Paraquat-induced lung injury: prevention by vasoactive intestinal peptide and related peptide helodermin.
We earlier showed that the neuropeptide vasoactive intestinal peptide (VIP) reduces or prevents acute injury produced in rat lungs by xanthine and xanthine oxidase. We have now examined whether VIPExpand
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Attenuation of Oxidant‐Induced Lung Injury by the Synthetic Matrix Metalloproteinase Inhibitor BB‐3103
Acute, diffuse lung injury often complicates sepsis, gastric acid aspiration, extensive trauma, and other conditions. The lung endothelial and epithelial cells are the early targets of this injuryExpand
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17β-estradiol protects the lung against acute injury: possible mediation by vasoactive intestinal polypeptide.
Beyond their classical role as a class of female sex hormones, estrogens (e.g. 17β-estradiol) exert important biological actions, both protective and undesirable. We have investigated the ability ofExpand
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Nitric Oxide Mediates Oxidant Tissue Injury Caused by Paraquat and Xanthine Oxidase
Abstract In both paraquat and X/XO models of lung injury, the injury, previously attributed to the generation of reactive oxygen species, was related to the induction of NO. synthesis, and wasExpand
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