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5-HT2C receptor agonists: pharmacological characteristics and therapeutic potential.
TLDR
The results suggest that 5-HT2C receptor agonism is associated with therapeutic potential in obsessive compulsive disorder and depression. Expand
Premature ejaculation and serotonergic antidepressants-induced delayed ejaculation: the involvement of the serotonergic system
TLDR
The neurophysiology and the peripheral neuroanatomy of ejaculation is described and a review of the involvement of serotonin in the central nervous system in relation to serotonergic nuclei and their projections is provided. Expand
Selective activation of 5HT1A receptors induces lower lip retraction in the rat
TLDR
The results suggest that, in vivo, functional interactions take place between the various 5HT receptors and the hypothesis that lower lip retraction is induced by compounds directly and selectively stimulating 5HT1A receptors is discussed. Expand
Behavioural evidence for functional interactions between 5‐HT‐receptor subtypes in rats and mice
TLDR
Interactions exist between the different 5‐HT receptor subtype‐mediated events, and care is needed in drawing conclusions from functional measurements when compounds have more or less equal affinities for more than one 5‐ HT‐receptor subtype. Expand
Depletion of brain serotonin differently affects behaviors induced by 5HT1A, 5HT1C, and 5HT2 receptor activation in rats.
TLDR
5HT1c receptors are more subject to denervation supersensitivity than 5HT1A and 5HT2 receptors, and this lesion model may be useful to discriminate behaviorally between direct and indirect activation of the 5 HT1c receptor. Expand
Modulation of 5-HT receptor subtype-mediated behaviours by corticosterone.
Malfunction of the serotonergic system and dysregulation of the hypothalamo-pituitary-adrenocortical axis have been implicated in the pathophysiology of depression. Several studies provide evidenceExpand
Stimulus properties of fluvoxamine in a conditioned taste aversion procedure
TLDR
5-HT1A receptors are involved in the stimulus properties of both fluvoxamine and fluoxetine, and the two SSRIs have somewhat different stimulus properties, based on the cross-comparison tests. Expand
Effect of metergoline, fenfluramine, and 8-OHDPAT on catalepsy induced by haloperidol or morphine
TLDR
The antagonistic effect of 8-OHDPAT suggests a secondary, modulating role for 5-HT1A receptor mediated events in both types of catalepsy, and concludes that serotonergic transmission plays a major role in effectuating morphine catalpesy but not inEffectuating haloperidol catalEPsy. Expand
Attenuation of 5-HT1A and 5-HT2 but not 5-HT1C receptor mediated behaviour in rats following chronic treatment with 5-HT receptor agonists, antagonists or antidepressants
TLDR
It is demonstrated that 5- HT1A and 5-HT2 but not5-HT1C receptor mediated behaviour can be attenuated by chronic treatment with agonists for these receptors. Expand
Drug-induced penile erections in rats: indications of serotonin1B receptor mediation.
TLDR
L-5-Hydroxy-tryptophan ( L-5HTP) induced penile erections when co-administered with nialamide and the peripheral decarboxylase inhibitor benserazide, indicating that the site of action for inducing penile erection is within the central nervous system. Expand
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