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Penetration of Titanium Dioxide Microparticles in a Sunscreen Formulation into the Horny Layer and the Follicular Orifice
TLDR
Deeper layers of the stratum corneum were devoid of TiO2 even after repetitive application of sunscreen preparation when analyzing interfollicular areas, and only in the areas of the pilosebaceous orifices could microparticles be identified.
Dynamics of human DNA topoisomerases IIα and IIβ in living cells
TLDR
Observations suggest that topo II is not an immobile, structural component of the chromosomal scaffold or the interphase karyoskeleton, but rather a dynamic interaction partner of such structures.
TDP1 Overexpression in Human Cells Counteracts DNA Damage Mediated by Topoisomerases I and II*
TLDR
Overexpression of the inactive mutant GFP-TDP1H263A at similar levels did not reduce DNA damage by camptothecin or VP-16, and observations confirm a requirement of active TDP1 for the repair of topoisomerase I-mediated DNA damage.
Distinct Effects of Topoisomerase I and RNA Polymerase I Inhibitors Suggest a Dual Mechanism of Nucleolar/Nucleoplasmic Partitioning of Topoisomerase I*
TLDR
Nucleolar/nucleoplasmic partitioning of topoisomerase I is regulated by interactions with RNA polymerase I and DNA but not by sumoylation, which is independent of the state of rRNA transcription.
The N-terminal Domain Anchors Human Topoisomerase I at Fibrillar Centers of Nucleoli and Nucleolar Organizer Regions of Mitotic Chromosomes*
TLDR
It is shown here that nucleolar accumulation of various fragments of topoisomerase I is correlated with their lesser mobility in this compartment and not with the N-terminal domain being intact or present, and that the N/A of the enzyme is not likely a nucleolar import signal.
Beware of the heart: the multiple picture of cardiac involvement in myositis.
TLDR
A 42-yr-old woman with dermatomyositis had two myocardial infarctions, episodes of acute chest pain and an acute lung oedema, which revealed a coincidence of small-vessel disease and vasospastic angina as a cause for the severe cardiac symptoms.
Anthocyanidins modulate the activity of human DNA topoisomerases I and II and affect cellular DNA integrity.
TLDR
Data indicate substantial affinity to double-stranded DNA, which might contribute at least to the DNA strand breaking effect of anthocyanidins at higher concentrations (> or = 50 microM).
Lycobetaine acts as a selective topoisomerase IIβ poison and inhibits the growth of human tumour cells
TLDR
In A431 cells immunoband-depletion of topoisomerase IIβ was induced, suggesting stabilization of the covalent catalytic DNA-intermediate in living cells, and it is reasonable to assume that this mechanism will cause or at least contribute significantly to the antitumour activity.
Changes in Mobility Account for Camptothecin-induced Subnuclear Relocation of Topoisomerase I* 210
TLDR
It is shown by photobleaching of cells expressing biofluorescent topoisomerase I-chimera that the enzyme moves continuously between nucleoli and nucleoplasm, which can plausibly be explained by the enzyme's 2-fold lesser overall mobility in nucleoli versusucleoplasm.
Detection of autoantibodies against tissue transglutaminase in patients with celiac disease and dermatitis herpetiformis
TLDR
Although tTG seems to be a major autoantigen in dermatitis herpetiformis, the low sensitivity of both tTG ELISA and immunofluorescence using human umbilical cord suggests differential involvement of tTG in this disease.
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