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Systemic Inflammation in Morbidly Obese Subjects: Response to Oral Supplementation with Alpha-Linolenic Acid
BackgroundMorbidly obese patients frequently display asymptomatic chronic activation of acute phase response, with potentially adverse metabolic and cardiovascular consequences. NutritionalExpand
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Omega-3 polyunsaturated fatty acids in treating non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled trial.
BACKGROUND & aims: Few clinical trials have addressed the potential benefits of omega-3 polyunsaturated fatty acids (PUFAs) on non-alcoholic steatohepatitis (NASH). We evaluated the effects ofExpand
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Vascular free radical release. Ex vivo and in vivo evidence for a flow-dependent endothelial mechanism.
Mechanisms underlying production of vascular free radicals are unclear. We hypothesized that changes in blood flow might serve as a physiological stimulus for endothelial free radical release. IntactExpand
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Immune cells and oxidative stress in the endotoxin tolerance mouse model.
Sepsis is a systemic inflammatory response that can lead to tissue damage and death. In order to increase our understanding of sepsis, experimental models are needed that produce relevant immune andExpand
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Liver mitochondrial dysfunction and oxidative stress in the pathogenesis of experimental nonalcoholic fatty liver disease.
Oxidative stress and hepatic mitochondria play a role in the pathogenesis of nonalcoholic fatty liver disease. The aim of the present study was to evaluate the role of hepatic mitochondrialExpand
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Sex-related differences in the response of spontaneously hypertensive rats to angiotensin-converting enzyme inhibitor.
We have compared the endothelium-dependent responses of thoracic aortic rings obtained from age-matched male and female SHR in order to explore gender differences in the effectiveness ofExpand
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An increase in mean platelet volume after admission is associated with higher mortality in critically ill patients
BackgroundPlatelet activation and consumption are common in critically ill patients and are associated with poorer prognosis. Mean platelet volume is a simple surrogate for platelet activation, withExpand
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Effects of hepatitis C virus on cardiovascular risk in infected patients: a comparative study.
The role of hepatitis C virus (HCV) in the pathogenesis of atherosclerosis and cardiovascular events is unclear. The aim of this study was to evaluate the direct effect of HCV on cardiovascular riskExpand
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Nitrated lipids decompose to nitric oxide and lipid radicals and cause vasorelaxation.
Nitric oxide-derived oxidants such as nitrogen dioxide and peroxynitrite have been receiving increasing attention as mediators of nitric oxide toxicity. Indeed, nitrated and nitrosated compounds haveExpand
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Pro- and Anti-inflammatory Cytokines in Steatosis and Steatohepatitis
BackgroundFatty liver disease is a problem in both bariatric patients and in patients with moderate obesity. Tumor necrosis factor (TNF)-α has been frequently measured in nonalcoholic steatohepatitisExpand
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