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Carbon-Nanotube Optoacoustic Lens for Focused Ultrasound Generation and High-Precision Targeted Therapy
  • H. Baac, J. Ok, +6 authors L. Guo
  • Materials Science, Medicine
  • Scientific reports
  • 18 December 2012
It is demonstrated that the optoacoustic lens can be used for micro-scale ultrasonic fragmentation of solid materials and a single-cell surgery in terms of removing the cells from substrates and neighboring cells. Expand
Low f-number photoacoustic lens for tight ultrasonic focusing and free-field micro-cavitation in water
We demonstrate a photoacoustic lens with a low f-number of 0.61 and a high focal gain of 220 at 15-MHz frequency for laser-generated focused ultrasound (LGFU), which enables free-fieldExpand
Nano-structural characteristics of carbon nanotube-polymer composite films for high-amplitude optoacoustic generation.
N nano-structural characteristics of carbon nanotube (CNT)-polydimethylsiloxane (PDMS) composite films that can be used as highly efficient and robust ultrasound transmitters for diagnostic and therapeutic applications and structure-originated characteristics manifest the CNT-PDMS composite films as excellent optoacoustic transmitter for high-amplitude and high-frequency ultrasound generation. Expand
Controlled Generation of Single Microbubble at Solid Surfaces by a Nanosecond Pressure Pulse
Optical excitation of a carbon nanotube composite is used to produce a high-amplitude, nanosecond-long pressure pulse, thus generating a single microbubble with high spatial accuracy. The resultingExpand
A 16-site neural probe integrated with a waveguide for optical stimulation
In this paper, we report a neural probe which can selectively stimulate target neurons optically from an integrated optical waveguide and also monitor extracellular neural signals in electricalExpand
Antibody-based surface plasmon resonance detection of intact viral pathogen.
SPR technique was used to directly detect an intact form of insect pathogen: the baculovirus, Autographa californica multiple nuclear polyhedrosis virus (AcMNPV), and serves as a prerequisite to the development of a new type of viral pathogen detection sensors. Expand
Optical measurement of neural activity using surface plasmon resonance.
It is demonstrated that surface plasmon resonance (SPR) is applicable to the optical detection of neural signals and the optical responses obtained from a rat sciatic nerve were highly correlated with simultaneously recorded electrical responses. Expand
Localized micro-scale disruption of cells using laser-generated focused ultrasound.
It is demonstrated that LGFU can be used as a non-contact, non-ionizing, high-precision tool to selectively detach a single cell from its culture substrate to explore the possibility of biomolecule delivery in a small population of cells targeted by LGFU at pressure amplitudes below and above the cavitation threshold. Expand
Micro-ultrasonic cleaving of cell clusters by laser-generated focused ultrasound and its mechanisms.
Fractionation processes are investigated in detail, which confirms distinct cell behaviors in the focal center and the periphery of LGFU spot, and possible mechanisms responsible for the focal and peripheral disruptions are discussed. Expand
Nozzle-Free Liquid Microjetting via Homogeneous Bubble Nucleation
We propose and demonstrate a physical mechanism for producing liquid microjets by taking an optoacoustic approach that can convert light to sound through a carbon-nanotube-coated lens, where lightExpand