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Phosphonomycin, a New Antibiotic Produced by Strains of Streptomyces
Phosphonomycin is a newly discovered antibiotic produced by streptomycetes. It is effective, when administered by the oral route, to mice infected with Gram-positive or Gram-negative microorganisms.…
Bacteriostatic and Bactericidal Substances Produced by a Soil Actinomyces.∗
Although Gram-negative bacteria are as a rule more resistant against the actinomycin than the Gram-positive forms, there is no sharp line of demarcation between the two groups and marked differences in sensitivity exist between the bacteria within each group.
Bacillin, a New Antibiotic Substance from a Soil Isolate of Bacillus subtilis
Of several actinomyQetes, fungi, and bacteria exhibiting antimycobacterial action, the aerobic sporeforming bacillus was selected for further study beause it formed an exceptionally large zone of inhibition.
Thienamycin, a new beta-lactam antibiotic. I. Discovery, taxonomy, isolation and physical properties.
A new beta-lactam antibiotic, named thienamycin, was discovered in culture broths of Streptomyces MA4297, and subsequently determined to be a hitherto unrecognized species, is designated StrePTomyces cattleya (NRRL 8057).
Streptothricin, a New Selective Bacteriostatic and Bactericidal Agent, Particularly Active Against Gram-Negative Bacteria.∗
A new type of antagonistic substance, designated as streptothricin, has been obtained from a soil Actinomyces and possesses also marked bactericidal properties, especially upon certain gram-negative bacteria.
Fosfomycin: Laboratory studies.
Fosfomycin, a nontoxic broad-spectrum antibiotic, different in structure from all previously described antibiotics, acts selectively by inhibiting cell wall formation and has favorable pharmacologic characteristics.
Actinomyces antibioticus, a New Soil Organism Antagonistic to Pathogenic and Non-pathogenic Bacteria
One species of Actinomyces proved to be particularly active against a great variety of bacteria and fungi, and was found to produce a specific bacteriostatic and bactericidal substance.
Cephamycins, a New Family of β-Lactam Antibiotics I. Production by Actinomycetes, Including Streptomyces lactamdurans sp. n
A number of actinomycetes isolated from soil were found to produce one or more members of a new family of antibiotics, the cephamycins, which are structurally related to cephalosporin C. The…
Microbiological Aspects of Penicillin
The critical studies outlined in this paper are based on experience with all the different types of assays and the conclusions presented are the result of the daily handling for approximately a year of 50 to 100 assays under practical working conditions.
The Soil as a Source of Microorganisms Antagonistic to Disease-Producing Bacteria
The soil was searched for bacterial agents of infectious diseases, until the conclusion was reached that these do not survive long in the soil, and the cause of the disappearance of these diseaseproducing organisms was suggested to be looked for.