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Cancer, pregnancy and fertility: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
TLDR
The aim of this work is to provide a systematic review and meta-analysis of the literature on canine coronavirus infection and its role in infertility and procreation that has been reported on in previous studies and is concerned with the well-being of newborns. Expand
Dissecting the heterogeneity of triple-negative breast cancer.
TLDR
The biology of TNBC at the pathologic and the molecular levels is discussed and the role of systemic therapies and the results of the first phase III clinical trial evaluating the addition of iniparib are elaborate. Expand
Prognostic impact of pregnancy after breast cancer according to estrogen receptor status: a multicenter retrospective study.
TLDR
Pregnancy after ER-positive BC does not seem to reduce the risk of BC recurrence, and DFS in the whole population, and overall survival (OS) were secondary objectives. Expand
An update on PARP inhibitors—moving to the adjuvant setting
TLDR
The evolution of PARP inhibitors from bench to bedside is described, and the up-to-date description of the key published or otherwise reported clinical trials of these agents are provided. Expand
Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): survival outcomes of a randomised, open-label, multicentre, phase 3 trial and their association with pathological complete
TLDR
The NeoALTTO trial showed that 3-year event-free survival was significantly improved for women who achieved pathological complete response compared with those who did not, and the association between pathological complete responded and overall survival was assessed. Expand
Cancer and fertility preservation: international recommendations from an expert meeting
TLDR
Although there is a great interest in this field, due to the lack of large prospective cohort studies and randomized trials on these topics, the level of evidence is not higher than 3 for most of the recommendations highlighting the need of further research efforts in many areas of this field. Expand
Elucidating Prognosis and Biology of Breast Cancer Arising in Young Women Using Gene Expression Profiling
TLDR
Proliferation-related prognostic gene signatures can aid treatment decision-making for young women, however, breast cancer arising at a young age seems to be biologically distinct beyond subtype distribution. Expand
Reproductive behaviors and risk of developing breast cancer according to tumor subtype: A systematic review and meta-analysis of epidemiological studies.
TLDR
This meta-analysis evaluated the association between parity, age at first birth, breastfeeding and the risk of developing breast cancer according to tumor subtype with available information on HR and HER2 to find the impact varies according to subtype. Expand
Prognosis of pregnancy-associated breast cancer: a meta-analysis of 30 studies.
TLDR
The results show that PABC is independently associated with poor survival particularly those diagnosed shortly post-partum, which underscores a possible impact of the pregnant breast microenvironment on the biology and consequently the prognosis of these tumors. Expand
Breast-feeding after breast cancer: if you wish, madam
TLDR
Different endocrinal, clinical and biological aspects dealing with breast-feeding after breast cancer are discussed in an attempt to determine how safe and feasible this approach is. Expand
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