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An evidence‐based causative classification system for acute ischemic stroke
- H. Ay, K. Furie, A. Singhal, Wade S. Smith, A. Sorensen, W. Koroshetz
- Medicine, PsychologyAnnals of neurology
- 1 November 2005
An algorithm that incorporated recent advances in stroke imaging and epidemiology to identify the most probable TOAST category in the presence of evidence for multiple mechanisms successfully classifies patients with acute ischemic stroke into determined etiologic categories without sacrificing reliabilty.
Posterior leukoencephalopathy without severe hypertension
Standard MRI confirms the diagnosis of posterior leukoencephalopathy syndrome (PLES), recently associated with an increasing number of medical conditions and ADC maps and DWI can successfully differentiate PLES from early cerebral ischemia, thus playing a pivotal role in treatment decisions.
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
A multiancestry genome-wide-association meta-analysis and discovered 22 new stroke risk loci, indicating mechanisms not previously implicated in stroke pathophysiology, with prioritization of risk variants and genes accomplished through bioinformatics analyses using extensive functional datasets.
Normal diffusion-weighted MRI during stroke-like deficits
Normal DWI in patients with stroke-like deficits should stimulate a search for nonischemic cause of symptoms, and more than one-half of such patients have an ischemic cause as the best clinical diagnosis.
Addition of brain and carotid imaging to the ABCD2 score to identify patients at early risk of stroke after transient ischaemic attack: a multicentre observational study
The prognosis for aphasia in stroke.
CT and conventional and diffusion-weighted MR imaging in acute stroke: study in 691 patients at presentation to the emergency department.
In the diagnosis of stroke in the early period (<6 hours after presentation to emergency department), DW MR imaging is superior to conventional MR imaging and CT.
A Computerized Algorithm for Etiologic Classification of Ischemic Stroke: The Causative Classification of Stroke System
An automated version of the SSS-TOAST, the Causative Classification System (CCS), is presented to facilitate its utility in multicenter settings and allows rapid analysis of patient data with excellent intra- and inter-examiner reliability, suggesting a potential utility in improving the fidelity of stroke classification in multicEnter trials or research databases in which accurate subtyping is critical.
Severity of Leukoaraiosis and Susceptibility to Infarct Growth in Acute Stroke
Because LA is associated with factors that modulate tissue perfusion as well as tissue capacity for handling of ischemia, LA volume appears to be a composite predictive marker for the fate of acutely ischemic tissue.
Association Between Atrial Fibrillation and Silent Cerebral Infarctions
A systematic review and meta-analysis of the literature was performed to estimate the association between AF and SCIs and the prevalence of SCIs in patients with AF and no history of symptomatic stroke.