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Insulin-Like Growth Factor System in Cancer: Novel Targeted Therapies
Insulin-like growth factors (IGFs) are essential for growth and survival that suppress apoptosis and promote cell cycle progression, angiogenesis, and metastatic activities in various cancers. TheExpand
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A tracked approach for automated NMR assignments in proteins (TATAPRO)
A novel automated approach for the sequence specific NMR assignments of 1HN, 13Cα, 13Cβ, 13C′/1Hα and 15N spins in proteins, using triple resonance experimental data, is presented. The algorithm,Expand
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Automated NMR assignments of proteins for high throughput structure determination: TATAPRO II
TATAPRO (Tracked Automated Assignments in Proteins), a novel algorithm for automated NMR assignments in proteins is presented to aid in high throughput protein structure determination. In thisExpand
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Enhanced stability and activity of an antimicrobial peptide in conjugation with silver nanoparticle.
The conjugation of nanoparticles with antimicrobial peptides (AMP) is emerging as a promising route to achieve superior antimicrobial activity. However, the nature of peptide-nanoparticleExpand
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Defining the pathway to insulin-like growth factor system targeting in cancer.
The insulin-like growth factors (IGFs; IGF-1 and IGF-2) play central roles in cell growth, differentiation, survival, transformation and metastasis. The biologic effects of the IGFs are mediated byExpand
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Rapid NMR data collection.
Rapid data collection is an area of intense research in biomolecular NMR spectroscopy, in particular for high-throughput structure determination in structural genomics. NMR data acquisition andExpand
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Selective `unlabeling' of amino acids in fractionally 13C labeled proteins: An approach for stereospecific NMR assignments of CH3 groups in Val and Leu residues
A novel methodology for stereospecific NMR assignments of methyl (CH3) groups of Val and Leu residues in fractionally 13C-labeled proteins is presented. The approach is based on selectiveExpand
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NMR studies of preimplantation embryo metabolism in human assisted reproductive techniques: a new biomarker for assessment of embryo implantation potential
There has been growing interest in understanding energy metabolism in human embryos generated using assisted reproductive techniques (ART) for improving the overall success rate of the method. UsingExpand
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NMR structure of the 18 kDa protein CC1736 from Caulobacter crescentus identifies a member of the “START” domain superfamily and suggests residues mediating substrate specificity
Yang Shen, Sharon Goldsmith-Fischman, Hanudatta S. Atreya, Thomas Acton, LiChung Ma, Rong Xiao, Barry Honig, Gaetano T. Montelione, and Thomas Szyperski* Department of Chemistry, University atExpand
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G-matrix Fourier transform NMR spectroscopy for complete protein resonance assignment.
  • H. Atreya, T. Szyperski
  • Materials Science, Medicine
  • Proceedings of the National Academy of Sciences…
  • 29 June 2004
A G-matrix Fourier transform (GFT) NMR spectroscopy-based strategy for resonance assignment of proteins is described. Each of the GFT NMR experiments presented here rapidly affords four-, five-, orExpand
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