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Cutting Edge: The Common γ-Chain Is an Indispensable Subunit of the IL-21 Receptor Complex1
The chemical cross-linking study reveals the direct binding of IL-21 to the γc, and clearly demonstrates that theγc is an indispensable subunit of the functional IL- 21R complex.
Cloning of the gamma chain of the human IL-2 receptor.
A third subunit, the gamma chain, of the human interleukin-2 receptor (IL-2R) was identified, and a complementary DNA clone encoding this member of the cytokine receptor family was isolated. The
Hrs Is Associated with STAM, a Signal-transducing Adaptor Molecule
The results suggest that Hrs counteracts the STAM function which is critical for cell growth signaling mediated by the cytokine-mediated intracellular signal transduction.
The interleukin-2 receptor gamma chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID.
The molecular identification of the gamma chain brought a grasp of the structures and functions of the cytokine receptor and an in-depth understanding of the cause of human XSCID.
Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads
The identification of a cytoplasmic protein, previously termed associated molecule with the SH3 domain of STAM (AMSH), as a direct binding partner for Smad6 is reported, suggesting that the molecular mechanism by which AMSH exerts its action is by inhibiting the binding of Smad 6 to activated type I receptors or activated R‐Smads.
The Role of G-Protein-Coupled Receptor Kinase 5 in Pathogenesis of Sporadic Parkinson's Disease
It is found that G-protein-coupled receptor kinase 5 (GRK5) accumulated in Lewy bodies and colocalized with α-synuclein in the pathological structures of the brains of sPD patients and suggests that phosphorylation of α- synuclein by GRK5 plays a crucial role in the pathogenesis of s PD.
Ligand‐Independent Degradation of Epidermal Growth Factor Receptor Involves Receptor Ubiquitylation and Hgs, an Adaptor Whose Ubiquitin‐Interacting Motif Targets Ubiquitylation by Nedd4
A ubiquitin‐interacting motif network is proposed that relays ubiquitylated membrane receptors to lysosomal degradation through successive budding events and targets self‐ubiquitylation by recruiting Nedd4, an ubiquitIn ligase previously implicated in endocytosis.
Possible Involvement of a Novel STAM-associated Molecule “AMSH” in Intracellular Signal Transduction Mediated by Cytokines*
It is suggested that AMSH plays a critical role in the cytokine-mediated intracellular signal transduction downstream of the Jak2/Jak3·STAM complex.
Human Parvovirus B19 Induces Cell Cycle Arrest at G2 Phase with Accumulation of Mitotic Cyclins
It is demonstrated that erythroblastoid UT7/Epo cells infected with B19 virus fall into growth arrest with 4N DNA, indicating G2/M arrest, which may be the critical event in the damage of erythroid progenitor cells seen in patients with B 19 virus infection.
Hgs (Hrs), a FYVE Domain Protein, Is Involved in Smad Signaling through Cooperation with SARA
It is demonstrated that Hgs, a FYVEdomain protein, binds to Smad2 in its C-terminal half and cooperates with another FYVE domain protein, the Smad anchor for receptor activation (SARA), to stimulate activin receptor-mediated signaling through efficient recruitment of Smad 2 to the receptor.