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Recombinant Human Bone Morphogenetic Protein-2 for Treatment of Open Tibial Fractures: A Prospective, Controlled, Randomized Study of Four Hundred and Fifty Patients
Background: The treatment of open fractures of the tibial shaft is often complicated by delayed union and nonunion. The objective of this study was to evaluate the safety and efficacy of the use ofExpand
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A standardized experimental fracture in the mouse tibia
The increased use of transgenic mice as experimental animals provides new opportunities to study the biology of fracture repair. We have developed a technique for the production of a standard closedExpand
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Recombinant human bone morphogenetic protein-2 in open tibial fractures. A subgroup analysis of data combined from two prospective randomized studies.
BACKGROUND The use of recombinant human bone morphogenetic protein-2 (rhBMP-2) to improve the healing of open tibial shaft fractures has been the focus of two prospective clinical studies. TheExpand
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The effect of rigidity on fracture healing in external fixation.
Knowledge of the basic biomechanics of external fixation is necessary to obtain the full benefits of the technique for bone fracture treatment. The rigidity of external fixation, including pin-boneExpand
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Intramedullary fixation of high subtrochanteric femoral fractures: a study comparing two implant designs, the Gamma nail and the intramedullary hip screw.
OBJECTIVE To compare two implants, the Gamma nail and the intramedullary hip screw (IMHS ), in the treatment of high subtrochanteric femoral fractures. STUDY DESIGN Prospective, nonrandomizedExpand
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Instrumented Spondylodesis in Degenerative Spondylolisthesis With Bioactive Glass and Autologous Bone: A Prospective 11-year Follow-up
A prospective long-term follow-up study of bioactive glass (BAG)-S53P4 and autogenous bone (AB) used as bone graft substitutes for posterolateral spondylodesis in treatment of degenerativeExpand
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Bone-healing patterns affected by loading, fracture fragment stability, fracture type, and fracture site compression.
  • H. Aro, E. Chao
  • Medicine
  • Clinical orthopaedics and related research
  • 1 August 1993
The major factors determining the mechanical milieu of a healing fracture are the rigidity of the selected fixation device, the fracture configuration, the accuracy of fracture reduction, and theExpand
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MicroRNAs miR‐96, miR‐124, and miR‐199a regulate gene expression in human bone marrow‐derived mesenchymal stem cells
MicroRNAs are small non‐coding RNAs that control gene expression at the post‐transcriptional level by binding to 3′‐untranslated regions (3′‐UTR) of their target mRNAs. They present a promising toolExpand
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Circulating plastic adherent mesenchymal stem cells in aged hip fracture patients
We examined the presence of circulating plastic adherent multipotent mesenchymal stem cells (MSCs) in fracture patients. Three patient groups (n = 10–18) were evaluated, including elderly femalesExpand
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Gene expression during bone repair.
Detailed understanding of the basic events in fracture healing constitutes a foundation for the development of new approaches to stimulate bone healing. Since the fracture healing process repeats, inExpand
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