• Publications
  • Influence
Diet-Induced Developmental Acceleration Independent of TOR and Insulin in C. elegans
Dietary composition has major effects on physiology. Here, we show that developmental rate, reproduction, and lifespan are altered in C. elegans fed Comamonas DA1877 relative to those fed a standardExpand
  • 165
  • 14
  • PDF
Single-Cell Analysis of Human Pancreas Reveals Transcriptional Signatures of Aging and Somatic Mutation Patterns
As organisms age, cells accumulate genetic and epigenetic errors that eventually lead to impaired organ function or catastrophic transformation such as cancer. Because aging reflects a stochasticExpand
  • 163
  • 7
Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function.
Intensive efforts are focused on identifying regulators of human pancreatic islet cell growth and maturation to accelerate development of therapies for diabetes. After birth, islet cell growth andExpand
  • 107
  • 7
Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory network
Gene regulatory networks (GRNs) provide insights into the mechanisms of differential gene expression at a systems level. GRNs that relate to metazoan development have been studied extensively.Expand
  • 83
  • 7
  • PDF
Matrix and Steiner-triple-system smart pooling assays for high-performance transcription regulatory network mapping
Yeast one-hybrid (Y1H) assays provide a gene-centered method for the identification of interactions between gene promoters and regulatory transcription factors (TFs). To date, Y1H assays haveExpand
  • 74
  • 6
  • PDF
Gene regulatory networks governing pancreas development.
Elucidation of cellular and gene regulatory networks (GRNs) governing organ development will accelerate progress toward tissue replacement. Here, we have compiled reference GRNs underlying pancreasExpand
  • 102
  • 6
Integration of Metabolic and Gene Regulatory Networks Modulates the C. elegans Dietary Response
Expression profiles are tailored according to dietary input. However, the networks that control dietary responses remain largely uncharacterized. Here, we combine forward and reverse genetic screensExpand
  • 65
  • 5
  • PDF
Gateway-compatible yeast one-hybrid screens.
INTRODUCTIONProtein-DNA interactions (PDIs) between transcription factors (TFs) and their target genes form the backbone of transcription regulatory networks. Such PDIs can be identified with eitherExpand
  • 73
  • 3
Gene-centered regulatory networks.
Differential gene expression plays a critical role in the development and physiology of multicellular organisms. At a 'systems level' (e.g. at the level of a tissue, organ or whole organism), thisExpand
  • 41
  • 3
  • PDF
The C. elegans Snail homolog CES-1 can activate gene expression in vivo and share targets with bHLH transcription factors
Snail-type transcription factors (TFs) are found in numerous metazoan organisms and function in a plethora of cellular and developmental processes including mesoderm and neuronal development,Expand
  • 39
  • 3
  • PDF