• Publications
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Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.
DJ-1 protects against neuronal oxidative stress, and loss of DJ-1 may lead to Parkinson's disease by conferring hypersensitivity to dopaminergic insults. Expand
Do early-life events permanently alter behavioral and hormonal responses to stressors?
It is suggested that genetic factors may influence dam–pup interactive styles and may thus proactively influence the response to subsequent stressors among vulnerable animals, in contrast, in relatively hardy animals the early‐life manipulations may have less obvious effects. Expand
Religiosity as Identity: Toward an Understanding of Religion From a Social Identity Perspective
Consideration of religion’s dual function as a social identity and a belief system may facilitate greater understanding of the variability in its importance across individuals and groups. Expand
Stress, depression, and anhedonia: Caveats concerning animal models
This review provides caveats concerning etiologically valid animal models of depression, focusing on characteristics of the depressive subtype being examined, and factors that contribute to the interindividual behavioral variability frequently evident in stressor-related behavioral paradigms. Expand
The intergenerational effects of Indian Residential Schools: Implications for the concept of historical trauma
These findings provide empirical support for the concept of historical trauma, which takes the perspective that the consequences of numerous and sustained attacks against a group may accumulate over generations and interact with proximal stressors to undermine collective well-being. Expand
Aversive and Appetitive Events Evoke the Release of Corticotropin-Releasing Hormone and Bombesin-Like Peptides at the Central Nucleus of the Amygdala
Results indicate that either food ingestion is interpreted as a “stressful” event by certain neural circuits involving the central amygdala or that the CRH- and BN-related peptidergic systems may serve a much broader role than previously envisioned. Expand
Calpain-Regulated p35/cdk5 Plays a Central Role in Dopaminergic Neuron Death through Modulation of the Transcription Factor Myocyte Enhancer Factor 2
Evidence is provided that calpain-p35-p25/cdk5-mediated inactivation of MEF2 plays a critical role in dopaminergic loss in vivo, and that “cdk 5 phosphorylation site mutant” ofMEF2D provides neuroprotection in an MPTP mouse model of PD. Expand
Cascading effects of stressors and inflammatory immune system activation: implications for major depressive disorder.
  • H. Anisman
  • Psychology, Medicine
  • Journal of psychiatry & neuroscience : JPN
  • 2009
This review provides synopses of the effects of traditional stressors on the release of corticotropin-releasing hormones at hypothalamic and extrahypothalamic sites, variations of serotonin and its receptors and changes of brain-derived neurotrophic factor (BDNF). Expand
Involvement of interferon-gamma in microglial-mediated loss of dopaminergic neurons.
It is reported here that PD patients express significantly elevated levels of IFN-gamma in their blood plasma, and the interactions between microglia and dopaminergic neurons in an in vitro mixedMicroglia/midbrain neuron rotenone-induced death paradigm suggest that IFN -gamma participates in death of dopamine neurons by regulating microglial activity. Expand
Endocrine and cytokine correlates of major depression and dysthymia with typical or atypical features
A role for interleukins may exist with respect to the pathophysiology of certain subtypes of depression, given that circulating cytokines influence neuroendocrine functioning, and may affect neurovegetative features. Expand