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A Novel Anti-Human HB-EGF Monoclonal Antibody with Multiple Antitumor Mechanisms against Ovarian Cancer Cells
TLDR
Results indicate that cKM3566 is a promising antiovarian cancer therapeutic antibody, which has a high binding reactivity for membrane-anchored HB-EGF expressed on the cell surface and exhibits potent in vivo antitumor activity.
Therapeutic antitumor efficacy of monoclonal antibody against Claudin‐4 for pancreatic and ovarian cancers
TLDR
The results suggest that mAb therapy against CLDN4 is promising for pancreatic and ovarian cancers.
Mouse-human chimeric anti-Tn IgG1 induced anti-tumor activity against Jurkat cells in vitro and in vivo.
TLDR
Results suggest that humanized antibody against clustered Tn-antigens is a promising therapeutic antibody against TN-positive cancers.
Establishment of monoclonal antibodies against cell surface domains of ASCT2/SLC1A5 and their inhibition of glutamine-dependent tumor cell growth.
TLDR
Evidence is provided supporting the use of MAbs against ASCT2 as an effective therapeutic strategy for cancer treatment and suppressing glutamine-dependent growth of WiDr colorectal cancer cells.
Cardiac microvascular endothelial cells express α-smooth muscle actin and show low NOS III activity.
TLDR
It is concluded that cardiac MVEC, in contrast to AEC, contain α-smooth muscle actin, show low-grade NOS III activity, and provide a suitable in vitro system for the study of endothelial pathophysiology.
Microvascular endothelial cells remodel cultured adult cardiomyocytes and increase their survival.
TLDR
The paracrine effect of cardiac microvascular endothelial cells (MVEC) on cultured adult rat cardiomyocytes (ARC) conditioned by serum-free medium (CM) is investigated, indicating a novel trophic factor in CM.
Surface free energy predominates in cell adhesion to hydroxyapatite through wettability.
TLDR
This study determined the optimal conditions of hydroxyapatite polarization for the improvement of surface wettability and acceleration of cell adhesion and investigated the effects of biomaterial surface characteristics on cellular behaviors.
Microvascular endothelial cells remodel cultured adult cardiomyocytes and increase their survival.
TLDR
The paracrine effect of cardiac microvascular endothelial cells (MVEC) on cultured adult rat cardiomyocytes (ARC) conditioned by serum-free medium (CM) is investigated, indicating a novel trophic factor in CM.
Characterization and evaluation of the antitumour activity of a dual-targeting monoclonal antibody against claudin-3 and claudin-4.
TLDR
A dual-targeting monoclonal antibody against CLDN3 and CLDN4 is a promising strategy for cancer immunotherapy.
Cardiac microvascular endothelial cells express alpha-smooth muscle actin and show low NOS III activity.
TLDR
It is concluded that cardiac MVEC, in contrast to AEC, contain alpha-smooth muscle actin, show low-grade NOS III activity, and provide a suitable in vitro system for the study of endothelial pathophysiology.
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