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Rapid-clearance iron nanoparticles for inflammation imaging of atherosclerotic plaque: initial experience in animal model.
PURPOSE To evaluate the use of a recently developed fast-clearing ultrasmall superparamagnetic iron oxide (USPIO) for detection of vascular inflammation in atherosclerotic plaque. MATERIALS ANDExpand
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Assessment of Age Modulated Vascular Inflammation in ApoE−/− Mice by USPIO-Enhanced Magnetic Resonance Imaging
Objective:Inflammation within atherosclerotic lesions increases the risk for plaque rupture and thrombosis. A functional approach to plaque analysis is the intravenous administration of ultrasmallExpand
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In vitro non-rigid life-size model of aortic arch aneurysm for endovascular prosthesis assessment.
PURPOSE It is essential to evaluate new stent designs before in vivo testing. The purpose of this study was to develop and validate a controlled and reproducible patient-derived process to produce aExpand
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Biomimetic MRI Contrast Agent for Imaging of Inflammation in Atherosclerotic Plaque of ApoE−/− Mice: A Pilot Study
Objective:Atherosclerosis involves an inflammatory process characterized by cellular and molecular responses. A slow-clearance blood-pool paramagnetic agent (CMD-A2-Gd-DOTA: P717) chemically modifiedExpand
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Technologies: preclinical imaging for drug development.
Preclinical imaging with magnetic resonance imaging (MRI), computerised tomography (CT), ultrasound (US), positron emission tomography (PET) or single-photon emission computed tomography (SPECT)Expand
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A new macromolecular paramagnetic MR contrast agent binds to activated human platelets.
A new functionalized macromolecular magnetic resonance (MR) contrast agent has been developed from a carboxymethyldextran-Gd(DOTA) devoid of biospecificity. The functionalized contrast agent wasExpand
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High‐resolution contrast‐enhanced MRI of atherosclerosis with digital cardiac and respiratory gating in mice
Atherosclerosis initially develops predominantly at the aortic root and carotid origin, where effective visualization in mice requires efficient cardiac and respiratory gating. The present studyExpand
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Real‐time gating system for mouse cardiovascular MR imaging
We demonstrate the feasibility of digital real‐time automatically updated gating methods, based on optimizing a signal‐processing technique for different mouse strains. Expand
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M1-Activated Macrophages Migration, A Marker of Aortic Atheroma Progression: A Preclinical MRI Study in Mice
Background:M1-activated Macrophages (M1M) play a major role in atherosclerotic lesions of aortic arch, promoting proinflammatory response. In vivo trafficking of M1M in aortic plaques is thereforeExpand
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In vivo cardiac anatomical and functional effects of wheel running in mice by magnetic resonance imaging
Physical activity is frequently used as a strategy to decrease pathogenesis and improve outcomes in chronic pathologies such as metabolic or cardiac diseases. In mice, it has been shown thatExpand
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