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Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity.
The unfolded protein response (UPR) is a signal transduction pathway that coordinates cellular adaptation to microenvironmental stresses that include hypoxia, nutrient deprivation, and change inExpand
An Orally Active TRPV4 Channel Blocker Prevents and Resolves Pulmonary Edema Induced by Heart Failure
Transient receptor potential vanilloid 4 (TRPV4) channels are expressed in human heart failure lungs, which can be blocked to prevent and resolve heart failure–induced pulmonary edema. Ion ChannelExpand
Albiglutide, a Long Lasting Glucagon-Like Peptide-1 Analog, Protects the Rat Heart against Ischemia/Reperfusion Injury: Evidence for Improving Cardiac Metabolic Efficiency
Background The cardioprotective effects of glucagon-like peptide-1 (GLP-1) and analogs have been previously reported. We tested the hypothesis that albiglutide, a novel long half-life analog ofExpand
Rapid-clearance iron nanoparticles for inflammation imaging of atherosclerotic plaque: initial experience in animal model.
PURPOSE To evaluate the use of a recently developed fast-clearing ultrasmall superparamagnetic iron oxide (USPIO) for detection of vascular inflammation in atherosclerotic plaque. MATERIALS ANDExpand
Assessment of Age Modulated Vascular Inflammation in ApoE−/− Mice by USPIO-Enhanced Magnetic Resonance Imaging
Objective:Inflammation within atherosclerotic lesions increases the risk for plaque rupture and thrombosis. A functional approach to plaque analysis is the intravenous administration of ultrasmallExpand
In vitro non-rigid life-size model of aortic arch aneurysm for endovascular prosthesis assessment.
PURPOSE It is essential to evaluate new stent designs before in vivo testing. The purpose of this study was to develop and validate a controlled and reproducible patient-derived process to produce aExpand
Retrospective cine 3He ventilation imaging under spontaneous breathing conditions: a non‐invasive protocol for small‐animal lung function imaging
A non‐invasive and free‐breathing hyperpolarized (HP) 3He imaging protocol for small animals was implemented and validated on rats for lung function imaging. Animals were allowed to breathe a mixtureExpand
Biomimetic MRI Contrast Agent for Imaging of Inflammation in Atherosclerotic Plaque of ApoE−/− Mice: A Pilot Study
Objective:Atherosclerosis involves an inflammatory process characterized by cellular and molecular responses. A slow-clearance blood-pool paramagnetic agent (CMD-A2-Gd-DOTA: P717) chemically modifiedExpand
High‐resolution contrast‐enhanced MRI of atherosclerosis with digital cardiac and respiratory gating in mice
Atherosclerosis initially develops predominantly at the aortic root and carotid origin, where effective visualization in mice requires efficient cardiac and respiratory gating. The present studyExpand
Real‐time gating system for mouse cardiovascular MR imaging
We demonstrate the feasibility of digital real‐time automatically updated gating methods, based on optimizing a signal‐processing technique for different mouse strains. Expand