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l -Metaraminol, but not d-metaraminol or α-methyl- m -tyramine, is rapidly taken up and retained by heart. After treatment with l -metaraminol or dl -α-methyl- m -tyrosine (α-MMT), metaraminolExpand
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Mode of action of antigen and other smooth-muscle stimulants.
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Release of Metaraminol (Aramine) from the Heart by Sympathetic Nerve Stimulation
Cats were injected intravenously with metaraminol, an amine which depletes norepinephrine from the sympathetic nerve endings; their hearts were then perfused in vitro. Stimulation of the sympatheticExpand
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The mechanism of the Schultz-Dale reaction.
Abstract 1.1. Evidence is presented supporting involvement of at least three humoral agents—histamine, serotonin, and acetylcholine—in the contraction of ileum from sensitized guinea pigs uponExpand
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The effects of chronic imipramine administration on rat brain levels of serotonin, 5-hydroxyindoleacetic acid, norepinephrine and dopamine.
The effects of chronic imipramine admimlistration on levels of serotonin, 5-hydroxyin doleacetic acid (5-HIAA), norepinephrine and dopamine in six areas of the brain were studied in four groups ofExpand
  • 51
Specific binding of reserpine. Association with norepinephrine depletion.
Abstract Small doses of 3 H-reserpine (10–100 μg/kg) were injected i.v. into rats and the drug concentration in heart, spleen and liver measured at various intervals. Eighteen hours after a dose ofExpand
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Inhibition of catecholamine uptake and retention in synaptosomal preparations by tetrahydroisoquinoline and tetrahydroprotoberberine alkaloids
Abstract The effects of racemic mixtures of representative tetrahydroisoquinoline and tetrahydroprotoberberine alkaloids on the mechanisms of catecholamine uptake and retention were studied inExpand
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Influence of catecholamine-derived alkaloids and beta-adrenergic blocking agents on stereospecific binding of 3H-naloxone.
Alkaloids containing a catecholamine moiety, viz., tetrahydroisoquinolines and tetrahydroprotoberberines, and a group of beta-adrenergic blocking agents were examined for their effects on the bindingExpand
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