H. Alpers

Publications18
h-index10
Citations496
Highly Influential Citations3
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BINDING AND RELEASE OF METARAMINOL: MECHANISM OF NOREPINEPHRINE DEPLETION BY ALPHA-METHYL-M-TYROSINE AND RELATED AGENTS.
l -Metaraminol, but not d-metaraminol or α-methyl- m -tyramine, is rapidly taken up and retained by heart. After treatment with l -metaraminol or dl -α-methyl- m -tyrosine (α-MMT), metaraminol… Expand
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Mode of action of antigen and other smooth-muscle stimulants.
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An in vitro study of the effects of tricyclic antidepressant drugs on the accumulation of C14-serotonin by rabbit brain.
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Release of Metaraminol (Aramine) from the Heart by Sympathetic Nerve Stimulation
Cats were injected intravenously with metaraminol, an amine which depletes norepinephrine from the sympathetic nerve endings; their hearts were then perfused in vitro. Stimulation of the sympathetic… Expand
  • 81
The mechanism of the Schultz-Dale reaction.
Abstract 1.1. Evidence is presented supporting involvement of at least three humoral agents—histamine, serotonin, and acetylcholine—in the contraction of ileum from sensitized guinea pigs upon… Expand
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Fluorometric estimation of meteraminol and related compounds
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The effects of chronic imipramine administration on rat brain levels of serotonin, 5-hydroxyindoleacetic acid, norepinephrine and dopamine.
The effects of chronic imipramine admimlistration on levels of serotonin, 5-hydroxyin doleacetic acid (5-HIAA), norepinephrine and dopamine in six areas of the brain were studied in four groups of… Expand
  • 51
Specific binding of reserpine. Association with norepinephrine depletion.
Abstract Small doses of 3 H-reserpine (10–100 μg/kg) were injected i.v. into rats and the drug concentration in heart, spleen and liver measured at various intervals. Eighteen hours after a dose of… Expand
  • 56
Inhibition of catecholamine uptake and retention in synaptosomal preparations by tetrahydroisoquinoline and tetrahydroprotoberberine alkaloids
Abstract The effects of racemic mixtures of representative tetrahydroisoquinoline and tetrahydroprotoberberine alkaloids on the mechanisms of catecholamine uptake and retention were studied in… Expand
  • 39
Influence of catecholamine-derived alkaloids and beta-adrenergic blocking agents on stereospecific binding of 3H-naloxone.
Alkaloids containing a catecholamine moiety, viz., tetrahydroisoquinolines and tetrahydroprotoberberines, and a group of beta-adrenergic blocking agents were examined for their effects on the binding… Expand
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