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The neuroprotective effect of tropisetron on vincristine-induced neurotoxicity.
TLDR
Investigation of a suppressive effect of tropisetron on VCR-induced neuropathy and whether this effect exerts through the 5-HT3 receptor or not demonstrates that tropisets could be a neuroprotective agent for prevention of V CR- induced neuropathy via a receptor-independent pathway. Expand
Fish Collagen: Extraction, Characterization, and Applications for Biomaterials Engineering
TLDR
An overview of the recent studies on collagen extraction from marine-based materials, in particular fish by-products, and biomaterials engineering and therapeutic applications of marine collagen are presented. Expand
Controlled Delivery of Nitric Oxide for Cancer Therapy
TLDR
The effects of NO in cancer biology, NO releasing moieties which can be used for NO delivery, and current advances in the design of NO releasing biomaterials focusing on their applications for tumor therapy are covered. Expand
Tropisetron ameliorates early diabetic nephropathy in streptozotocin‐induced diabetic rats
TLDR
The present study suggests that tropisetron may be a protective agent in early diabetic nephropathy, and its action is mediated, at least in part, by anti‐oxidative and anti‐inflammatory mechanisms that appear to be independent of the 5‐HT3 receptor. Expand
Inhibition of calcineurin/NFAT pathway plays an essential role in renoprotective effect of tropisetron in early stage of diabetic nephropathy.
TLDR
Results showed that tropisetron could ameliorate kidney injury in the early stage of diabetic nephropathy in rats, and can be attributed, at least in part, to the suppression of diabetes-induced increases in calcineurin expression in kidney tissue. Expand
Pantoprazole, a proton pump inhibitor, increases orthodontic tooth movement in rats
TLDR
Long term PPI therapy at high doses could lead to osteoporosis and enhanced OTM. Expand
Nitric oxide-releasing nanoparticles improve doxorubicin anticancer activity
TLDR
SMA-tDodSNO can be used as a successful strategy to increase the efficacy of Dox and SMA-Dox in a model of triple-negative breast cancer, without causing significant toxicity as monitored through body weight loss. Expand
Hypoxia Responsive Drug Delivery Systems in Tumor Therapy.
TLDR
Four main hypoxia responsive delivery systems are discussed: polymeric based drug delivery systems, oxygen delivery systems combined with radiotherapy and chemotherapy, anaerobic bacteria which are used for delivery of genes to express anticancer proteins such as tumor necrosis alpha (TNF-α) and hypoxIA-inducible transcription factors 1 alpha (HIF1α) responsive gene delivery systems. Expand
Pretreatment of CAV Combination Chemotherapy with Tropisetron Shows Less Cardio and Neurotoxicity Side Effects in Rats
TLDR
It is suggested that tropisetron is beneficial for the prevention of cardiotoxicity and neurotoxicity and could be considered as a new indication for alleviation of side effects of these drugs in combination therapies. Expand
Effects of Juglans regia L. leaf extract on hyperglycemia and lipid profiles in type two diabetic patients: a randomized double-blind, placebo-controlled clinical trial.
TLDR
Treatment of type II diabetic patients with 100mg Juglans regia leaf extract two times a day for three months improves lipid profile and glycemic control without any tangible adverse effects. Expand
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