H. Alenius

Publications319
h-index63
Citations16,376
Highly Influential Citations544
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CCL27–CCR10 interactions regulate T cell–mediated skin inflammation
TLDR
It is reported that most skin-infiltrating lymphocytes in patients suffering from psoriasis, atopic or allergic-contact dermatitis express CCR10, indicating that CCL27–CCR10 interactions have a pivotal role in T cell–mediated skin inflammation.
MicroRNAs: Novel Regulators Involved in the Pathogenesis of Psoriasis?
TLDR
It is shown for the first time that psoriasis-affected skin has a specific microRNA expression profile when compared with healthy human skin or with another chronic inflammatory skin disease, atopic eczema.
IL-31: a new link between T cells and pruritus in atopic skin inflammation.
Environmental biodiversity, human microbiota, and allergy are interrelated
TLDR
Analyzing atopic sensitization in a random sample of adolescents living in a heterogeneous region of 100 × 150 km, it is shown that environmental biodiversity in the surroundings of the study subjects’ homes influenced the composition of the bacterial classes on their skin.
Cumulative meta-analysis of interleukins 6 and 1β, tumour necrosis factor α and C-reactive protein in patients with major depressive disorder
A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1.
Sleep Restriction Increases the Risk of Developing Cardiovascular Diseases by Augmenting Proinflammatory Responses through IL-17 and CRP
TLDR
5 nights of sleep restriction increased lymphocyte activation and the production of proinflammatory cytokines including IL-1β IL-6 and IL-17; they remained elevated after 2 nights of recovery sleep, accompanied by increased heart rate and serum CRP, 2 important risk factors for cardiovascular diseases.
(1,3)-β-Glucans Activate Both Dectin-1 and NLRP3 Inflammasome in Human Macrophages
TLDR
The results show that β-glucans are recognized by membrane-associated dectin-1 and cytoplasmic NLRP3 inflammasome resulting in IL-1β gene transcription and IL- 1β secretion in human macrophages, respectively.
Socioeconomic status and the 25 × 25 risk factors as determinants of premature mortality: a multicohort study and meta-analysis of 1·7 million men and women
Long, needle-like carbon nanotubes and asbestos activate the NLRP3 inflammasome through a similar mechanism.
TLDR
Investigating whether different CNM induce a pro-inflammatory response in human primary macrophages provides new information about the mechanisms by which long, needle-like materials may cause their harmful health effects and may be of use in future risk assessments of nanomaterials.
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