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CCL27–CCR10 interactions regulate T cell–mediated skin inflammation
It is reported that most skin-infiltrating lymphocytes in patients suffering from psoriasis, atopic or allergic-contact dermatitis express CCR10, indicating that CCL27–CCR10 interactions have a pivotal role in T cell–mediated skin inflammation.
MicroRNAs: Novel Regulators Involved in the Pathogenesis of Psoriasis?
It is shown for the first time that psoriasis-affected skin has a specific microRNA expression profile when compared with healthy human skin or with another chronic inflammatory skin disease, atopic eczema.
IL-31: a new link between T cells and pruritus in atopic skin inflammation.
Environmental biodiversity, human microbiota, and allergy are interrelated
Analyzing atopic sensitization in a random sample of adolescents living in a heterogeneous region of 100 × 150 km, it is shown that environmental biodiversity in the surroundings of the study subjects’ homes influenced the composition of the bacterial classes on their skin.
Sleep Restriction Increases the Risk of Developing Cardiovascular Diseases by Augmenting Proinflammatory Responses through IL-17 and CRP
5 nights of sleep restriction increased lymphocyte activation and the production of proinflammatory cytokines including IL-1β IL-6 and IL-17; they remained elevated after 2 nights of recovery sleep, accompanied by increased heart rate and serum CRP, 2 important risk factors for cardiovascular diseases.
(1,3)-β-Glucans Activate Both Dectin-1 and NLRP3 Inflammasome in Human Macrophages
The results show that β-glucans are recognized by membrane-associated dectin-1 and cytoplasmic NLRP3 inflammasome resulting in IL-1β gene transcription and IL- 1β secretion in human macrophages, respectively.
Long, needle-like carbon nanotubes and asbestos activate the NLRP3 inflammasome through a similar mechanism.
Investigating whether different CNM induce a pro-inflammatory response in human primary macrophages provides new information about the mechanisms by which long, needle-like materials may cause their harmful health effects and may be of use in future risk assessments of nanomaterials.