Relative contributions of myeloperoxidase and NADPH-oxidase to the early host defense against pulmonary infections with Candida albicans and Aspergillus fumigatus.
- Y. Aratani, F. Kura, H. Koyama
- BiologyMedical Mycology
- 1 December 2002
The results suggest that superoxide (O2-) produced by NADPH-oxidase is more important than hypochlorous acid (HOCl) produced by MPO, although both oxidative products obviously contribute to the host defense against pulmonary infection with those fungi.
Differential host susceptibility to pulmonary infections with bacteria and fungi in mice deficient in myeloperoxidase.
- Y. Aratani, F. Kura, H. Koyama
- Biology, MedicineJournal of Infectious Diseases
- 1 October 2000
The results suggest that the MPO-dependent oxidative system is important for host defense against fungi and bacteria, although the effect varies by pathogen species.
A plasmid involved in chloramphenicol production in Streptomyces venezuelae: evidence from genetic mapping.
- H. Akagawa, M. Okanishi, H. Umezawa
- Biology, EngineeringJournal of General Microbiology
- 1 October 1975
It is concluded that chloramphenicol production is controlled by a plasmid that appeared to be non-transferable in conjugation.
Mer-NF5003B, E and F, novel sesquiterpenoids as avian myeloblastosis virus protease inhibitors produced by Stachybotrys sp.
- R. Kaneto, K. Dobashi, S. Mizuno
- ChemistryJournal of antibiotics (Tokyo. )
- 25 June 1994
The rpoZ Gene, Encoding the RNA Polymerase Omega Subunit, Is Required for Antibiotic Production and Morphological Differentiation in Streptomyces kasugaensis
- Ikuo Kojima, K. Kasuga, H. Akagawa
- BiologyJournal of Bacteriology
- 1 December 2002
This study established that rpoZ is required for kasugamycin production and aerial mycelium formation in S. kasugaensis and responsible for pleiotropy.
14CO2-Fixation in Marine Algae with Special Reference to the Dark-Fixation in Brown Algae
- H. Akagawa, T. Ikawa, K. Nisizawa
- Biology
- 1972
An evaluation of taxonomic criteria in streptomycetes on the basis of deoxyribonucleic acid homology.
- M. Okanishi, H. Akagawa, H. Umezawa
- BiologyJournal of General Microbiology
- 1 August 1972
The suitability of several diagnostic features as taxonomic criteria are discussed, and the DNAs of streptomycetes in the largest subgroup were found to be highly homologous to DNA from S. californicus ISP 5058 located in that subgroup.
Critical role of myeloperoxidase and nicotinamide adenine dinucleotide phosphate-oxidase in high-burden systemic infection of mice with Candida albicans.
- Y. Aratani, F. Kura, H. Koyama
- Biology, MedicineJournal of Infectious Diseases
- 15 June 2002
It is suggested that MPO and NADPH-oxidase are equally important for early host defense against a large inoculum of Candida.
Contribution of the myeloperoxidase-dependent oxidative system to host defence against Cryptococcus neoformans.
- Y. Aratani, F. Kura, H. Koyama
- Biology, MedicineJournal of Medical Microbiology
- 1 September 2006
A major role is suggested in immunological defence against Cryptococcus neoformans in an MPO-deficient (MPO-/-) mouse model, with more severe pneumonia than wild-type mice, which was associated with an increase in the levels of IL-1alpha/beta in the lungs.
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