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Sequential activation of signaling pathways during innate immune responses in Drosophila.
Innate immunity is essential for metazoans to fight microbial infections. Genome-wide expression profiling was used to analyze the outcome of impairing specific signaling pathways after microbialExpand
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Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury.
To characterize the features of JAK/STAT signaling in Drosophila immune response, we have identified totA as a gene that is regulated by the JAK/STAT pathway in response to septic injury. We showExpand
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PlcR is a pleiotropic regulator of extracellular virulence factor gene expression in Bacillus thuringiensis
Members of the Bacillus cereus group (B. anthracis, B. cereus, B. mycoides and B. thuringiensis ) are well‐known pathogens of mammals (B. anthracis and B. cereus ) and insects (B. thuringiensis ).Expand
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RNA interference screen for human genes associated with West Nile virus infection
West Nile virus (WNV), and related flaviviruses such as tick-borne encephalitis, Japanese encephalitis, yellow fever and dengue viruses, constitute a significant global human health problem. However,Expand
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The Lipid Transfer Protein CERT Interacts with the Chlamydia Inclusion Protein IncD and Participates to ER-Chlamydia Inclusion Membrane Contact Sites
Bacterial pathogens that reside in membrane bound compartment manipulate the host cell machinery to establish and maintain their intracellular niche. The hijacking of inter-organelle vesicularExpand
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The roles of JAK/STAT signaling in Drosophila immune responses
Summary:  Innate immune responses are mediated by the activation of various signaling processes. Here, we describe our current knowledge on Janus kinase (JAK)/signal transducers and activators ofExpand
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Rab 5 Is Required for the Cellular Entry of Dengue and West Nile Viruses
ABSTRACT The mechanisms of cellular entry of dengue and West Nile viruses are not well characterized. We show that both these viruses enter HeLa cells by clathrin-dependent endocytosis and requireExpand
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Genome-Wide RNAi Screen for Host Factors Required for Intracellular Bacterial Infection
Most studies of host-pathogen interactions have focused on pathogen-specific virulence determinants. Here, we report a genome-wide RNA interference screen to identify host factors required forExpand
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How does Bacillus thuringiensis produce so much insecticidal crystal protein?
Members of the genusBacillusare widely used as sources of industrial enzymes, fine biochemicals, antibiotics, and insecti- cides (for a review, see reference 27). One of these species, BacillusExpand
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Identification of a Bacillus thuringiensis gene that positively regulates transcription of the phosphatidylinositol-specific phospholipase C gene at the onset of the stationary phase.
A transcriptional analysis of the phosphatidylinositol-specific phospholipase C (plcA) gene of Bacillus thuringiensis indicated that its transcription was activated at the onset of the stationaryExpand
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