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wishful thinking Encodes a BMP Type II Receptor that Regulates Synaptic Growth in Drosophila
TLDR
Wishful thinking appears to function as a presynaptic receptor that regulates synaptic size at the Drosophila NMJ, a gene that positively regulates synaptic growth.
β‐catenin is a target for the ubiquitin–proteasome pathway
TLDR
It is shown that ubiquitination of β‐catenin is greatly reduced in Wnt‐expressing cells, providing the first evidence that the ubiquitin–proteasome degradation pathway may act downstream of GSK3β in the regulation ofβ‐ catenin.
The expression pattern of the Drosophila vesicular glutamate transporter: a marker protein for motoneurons and glutamatergic centers in the brain.
TLDR
The identification of the enhancer trap line OK371-Gal4, which is expressed in a defined subset of neurons from embryonic stage 15 to adulthood, and found that the DVGLUT-specific antibodies are valuable tools for the identification of motoneurons and other glutamatergic neurons.
beta-catenin is a target for the ubiquitin-proteasome pathway.
TLDR
It is shown that ubiquitination of beta-catenin is greatly reduced in Wnt-expressing cells, providing the first evidence that the ubiquitin-proteasome degradation pathway may act downstream of GSK3beta in the regulation of Beta-Catenin.
Highwire Regulates Presynaptic BMP Signaling Essential for Synaptic Growth
TLDR
Results reveal a balance between positive BMP signaling and negative regulation by Highwire, governing the growth of neuromuscular synapses.
Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor
TLDR
It is suggested that catenins represent an important link between EGF-induced signal transduction and cadherin function.
Assembly of the cadherin-catenin complex in vitro with recombinant proteins.
TLDR
The reconstitution in vitro of the cadherin-catenin complex should allow the study of the interaction with signalling molecules and with the actin-based cytoskeleton.
Drosophila Neuroligin 1 Promotes Growth and Postsynaptic Differentiation at Glutamatergic Neuromuscular Junctions
TLDR
Several mutant alleles of Drosophila neuroligin 1 (dnlg1) that cause a severe reduction in bouton numbers at neuromuscular junctions (NMJs) are recovered and, in accord with reduced synapse numbers, these NMJs show reduced synaptic transmission.
E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF-1-mediated transactivation.
TLDR
Using recombinant proteins, it is found that E-cadherin and lymphocyte-enhancer factor-1 (LEF-1) form mutually exclusive complexes with beta-catenin; the association of beta-Catenin with LEf-1 was competed out by the E- cadher in cytoplasmic domain.
Drosophila Ankyrin 2 Is Required for Synaptic Stability
TLDR
Interestingly, Ank2 functions downstream of spectrin in the anchorage of synaptic microtubules, providing the cytoskeletal scaffold that is essential for synaptic stability.
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