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Molecular mechanisms of transcription activation by HLF and HIF1α in response to hypoxia: their stabilization and redox signal‐induced interaction with CBP/p300
Hypoxia‐inducible factor 1 α (HIF1α) and its related factor, HLF, activate expression of a group of genes such as erythropoietin in response to low oxygen. Transfection analysis using fusion genes of… Expand
XAIP1: a Xenopus homologue of yeast actin interacting protein 1 (AIP1), which induces disassembly of actin filaments cooperatively with ADF/cofilin family proteins.
We carried out affinity column chromatography using Xenopus ADF/cofilin (XAC), identified several polypeptides in oocytes specifically bound to this column with actin, and isolated a full-length cDNA… Expand
The mammalian oviductal epithelium : regional variations in cytological and functional aspects of the oviductal secretory cells
- H. Abe
Sumrnary. The secretory cells in the epithelium of mammalian oviducts produce and release various secretory matenals into the lumen. Secretions from such cells provide a suitable environment for the… Expand
Intracellular pH modulation of ADF/cofilin proteins.
- B. W. Bernstein, W. Painter, H. Chen, L. Minamide, H. Abe, J. Bamburg
- Medicine, Biology
- Cell motility and the cytoskeleton
- 1 December 2000
The ADF/cofilin (AC) proteins are necessary for the high rates of actin filament turnover seen in vivo. Their regulation is complex enough to underlie the precision in filament dynamics needed by… Expand
HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity
In severely hypoxic condition, HIF-1α-mediated induction of Pdk1 was found to regulate glucose oxidation by preventing the entry of pyruvate into the tricarboxylic cycle. Monocyte-derived… Expand
The Roles of Hypoxia Signaling in the Pathogenesis of Cardiovascular Diseases
The circulatory system distributes blood flow to each tissue and transports oxygen and nutrients. Peripheral circulation is required to maintain the physiological function in each tissue. Disturbance… Expand
Site-directed mutagenesis of the phosphorylation site of cofilin: its role in cofilin-actin interaction and cytoplasmic localization.
It has been demonstrated that the activity of ADF and cofilin, which constitute a functionally related protein family, is markedly altered by phosphorylation, and that the phosphorylation site is Ser… Expand
Effects of cofilin on actin filamentous structures in cultured muscle cells. Intracellular regulation of cofilin action.
The previous investigation (Abe et al. (1989) J. Biochem. 106, 696-702) suggested that cofilin is deeply involved in the regulation of actin assembly in developing skeletal muscle. In this study, to… Expand
The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition
- Justin Goodwin, Michael L. Neugent, +20 authors J. Kim
- Biology, Medicine
- Nature communications
- 26 May 2017
Adenocarcinoma (ADC) and squamous cell carcinoma (SqCC) are the two predominant subtypes of non-small cell lung cancer (NSCLC) and are distinct in their histological, molecular and clinical… Expand
A cofilin-like protein is involved in the regulation of actin assembly in developing skeletal muscle.
An actin-binding protein of 20 kDa (called 20K protein) was purified from the sarcoplasmic fraction of embryonic chicken skeletal muscle. The properties of this protein were very similar to cofilin,… Expand