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PATTERNS OF SPECIATION IN DROSOPHILA
  • J. Coyne, H. A. Orr
  • Biology, Medicine
  • Evolution; international journal of organic…
  • 1 March 1989
TLDR
To investigate the time course of speciation, literature data is gathered on 119 pairs of closely related Drosophila species with known genetic distances, mating discrimination, strength of hybrid sterility and inviability, and geographic ranges to provide a cross‐section of taxa at different stages ofSpeciation. Expand
The population genetics of speciation: the evolution of hybrid incompatibilities.
  • H. A. Orr
  • Biology, Medicine
  • Genetics
  • 1 April 1995
TLDR
The number of genic incompatibilities between taxa increases much faster than linearly with time, and it is "easier" to evolve complex hybrid incomp atibilities requiring the simultaneous action of three or more loci than to evolve simple incompatibles between pairs of genes. Expand
THE POPULATION GENETICS OF ADAPTATION: THE DISTRIBUTION OF FACTORS FIXED DURING ADAPTIVE EVOLUTION
  • H. A. Orr
  • Biology, Medicine
  • Evolution; international journal of organic…
  • 1 August 1998
TLDR
Using Fisher's geometric model of adaptation, this work derives an approximate solution to the size distribution of factors fixed during adaptation, which is remarkably insensitive to changes in the fitness function and in the distribution of mutational effects. Expand
“PATTERNS OF SPECIATION IN DROSOPHILA” REVISITED
  • J. Coyne, H. A. Orr
  • Biology, Medicine
  • Evolution; international journal of organic…
  • 1 February 1997
TLDR
The data from Drosophila are unique-and are likely to remain so-because of the large number of crossable species and the ease of estimating sexual and postzygotic isolation in the laboratory, and some estimates of reproductive isolation and phylogenetic relatedness when better data became available are revised. Expand
The genetic theory of adaptation: a brief history
  • H. A. Orr
  • Biology, Medicine
  • Nature Reviews Genetics
  • 1 February 2005
TLDR
The history of adaptation theory is surveyed, focusing on the rise and fall of various views over the past century and the reasons for the slow development of a mature theory of adaptation. Expand
ADAPTATION AND THE COST OF COMPLEXITY
  • H. A. Orr
  • Biology, Medicine
  • Evolution; international journal of organic…
  • 1 February 2000
TLDR
The rate at which fitness increases during adaptation is calculated and the curve giving fitness versus time as a population approaches an optimum in Fisher's model of adaptation is described, suggesting that one can define an effective number of dimensions characterizing an adapting species. Expand
Testing natural selection vs. genetic drift in phenotypic evolution using quantitative trait locus data.
  • H. A. Orr
  • Biology, Medicine
  • Genetics
  • 1 August 1998
TLDR
It is argued that data from quantitative trait locus (QTL) analyses can be used to test the null hypothesis of neutral phenotypic evolution, and a sign test is proposed that compares the observed number of plus and minus alleles in the "high line" with that expected under neutrality. Expand
The evolutionary genetics of speciation.
  • J. Coyne, H. A. Orr
  • Biology, Medicine
  • Philosophical transactions of the Royal Society…
  • 28 February 1998
TLDR
Defining speciation as 'the origin of reproductive isolation between two taxa' is defined, and some important and tractable questions about speciation that have been neglected are pointed out. Expand
THE EVOLUTION OF POSTZYGOTIC ISOLATION: ACCUMULATING DOBZHANSKY‐MULLER INCOMPATIBILITIES
  • H. A. Orr, M. Turelli
  • Biology, Medicine
  • Evolution; international journal of organic…
  • 1 June 2001
TLDR
The distribution of the number of incompatibilities as a function of divergence time between allopatric taxa as well as the distribution of waiting times to speciation by postzygotic isolation are derived. Expand
Population Extinction and the Genetics of Adaptation
TLDR
This work derives simple, though approximate, solutions to the probability of successful adaptation (population survival) when adaptation involves new mutations, the standing genetic variation, or a mixture of the two. Expand
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