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Tau protein in cerebrospinal fluid: a biochemical marker for axonal degeneration in Alzheimer disease?
- K. Blennow, A. Wallin, H. Ågren, C. Spenger, J. Siegfried, E. Vanmechelen
- BiologyMolecular and chemical neuropathology
- 1 December 1995
It is demonstrated that elevated tau/PHFtau levels are consistently found in CSF of AD patients and CSF-tau may therefore be useful as a positive biochemical marker, to discriminate AD from normal aging, PD, and depressive pseudodementia.
Decreased cerebrospinal fluid neuropeptide Y (NPY) in patients with treatment refractory unipolar major depression: preliminary evidence for association with preproNPY gene polymorphism.
Tau and Abeta42 in cerebrospinal fluid from healthy adults 21-93 years of age: establishment of reference values.
These reference values can be applied when using CSF-tau and CSf-Abeta42 in clinical practice and no correlation was found between blood-brain barrier function and CSF -tau orCSF- Abeta42.
The mission is remission: health economic consequences of achieving full remission with antidepressant treatment for depression
- P. Sobocki, M. Ekman, H. Ågren, B. Runeson, B. Jönsson
- Medicine, PsychologyInternational journal of clinical practice
- 1 July 2006
It is concluded that remission has a substantial health economic impact on patients treated for depression, which further strengthens the importance of aiming for full remission in the treatment of depression.
Adaptation of the multidimensional scale of perceived social support in a Ugandan setting.
- J. Nakigudde, S. Musisi, A. Ehnvall, E. Airaksinen, H. Ågren
- Medicine, PsychologyAfrican health sciences
- 1 August 2009
The adapted MSPSS can reliably be used in Uganda and demonstrated good internal consistency at .83, and three subscales that had been identified in other populations were evident in the Ugandan population.
Effect of buspirone on sexual dysfunction in depressed patients treated with selective serotonin reuptake inhibitors.
- M. Landén, E. Eriksson, H. Ågren, T. Fahlén
- Psychology, MedicineJournal of clinical psychopharmacology
- 1 June 1999
It is suggested that the effect of buspirone on sexual dysfunction is a result of a reversal of SSRI-induced sexual side effects rather than of an antidepressant effect of the drug.
Health-related quality of life measured with EQ-5D in patients treated for depression in primary care.
The results indicate that treatments for depression are associated with significant improvement in EQ-5D index score over a course of 6 months, and self-reported patient valuations are important outcomes for cost-utility analysis of new treatments for Depression.
Neuropeptide Y and corticotropin-releasing hormone in CSF mark response to antidepressive treatment with citalopram.
- G. Nikisch, H. Ågren, C. Eap, A. Czernik, P. Baumann, A. Mathé
- PsychologyThe international journal of…
- 1 September 2005
Significant NPY and CRH changes in CSF following treatment as well as correlations to changes in HAMD support the hypothesis that these two peptides play a role in affective disorders and are markers of therapeutic response.
Increased incidence of CYP2D6 gene duplication in patients with persistent mood disorders: ultrarapid metabolism of antidepressants as a cause of nonresponse. A pilot study
- C. Kawanishi, S. Lundgren, H. Ågren, L. Bertilsson
- Medicine, PsychologyEuropean Journal of Clinical Pharmacology
The results suggest that the CYP2D6 gene duplication is a possible factor that influences the development of persistence in patients with mood disorders probably by ultrarapid drug metabolism.
The prevalence of insomnia: the importance of operationally defined criteria.
- B. Liljenberg, M. Almqvist, J. Hetta, B. Roos, H. Ågren
- Psychology, MedicineAnnals of clinical research
The prevalence of insomnia in members of the population aged 30 to 65 years from two geographically different rural parts of central Sweden is lower than previously reported, demonstrating the importance of an operational definition of insomnia.