H. van Ormondt

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A tumor stems from the derailment of a single cell. Not unreasonably, it has been assumed that such a dysfunction is caused by somatic mutations inactivating one or more of the finely tuned regulatory systems that govern cellular systems. In recent years, however, it has become evident that in some cases the cancerous state is not due to inactivation but to(More)
The sequence of 29 nucleotides in the region preceding the initiation of the transcription of the Escherichia coli tyrosine tRNA gene has been determined. This is: (5') ---GGGGCGCATCATATCAAATGACGCGCCGC--- (3') (3') ---CCCCGCGTAGTATAGTTTACTGCGGCGGCG--- (5'). The general approach used for the sequence determination involved the DNA polymerase I-catalyzed(More)
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