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The twin-screw hot-melt extrusion process is useful for preparing solid dispersions which can improve the dissolution and absorption of drugs. The kneading paddle elements of the screws play an important role in changing the crystallinity and dissolution properties of a solid dispersion of kneaded nifedipine-hydroxypropylmethylcellulose phthalate(More)
A floating dosage form composed of nicardipine hydrochloride (NH) and hydroxypropylmethylcellulose acetate succinate (enteric polymer) was prepared using a twin-screw extruder. By adjusting the position of the high-pressure screw elements in the immediate vicinity of die outlet, and by controlling the barrel temperature, we were able to prepare a puffed(More)
Sodium guaiazulene sulfonate (GAS-Na), which has an anti-inflammatory effect, is an unstable compound, which is gradually decomposed in the solid state at room temperature. In fact, when heated (40 degrees C 6% RH), GAS-Na decomposes almost completely within 1 week. It was found that a kneaded mixture of GAS-Na and cornstarch (weight ratio; 1:250) for(More)
This paper presents a novel approach for system design, the functional redundancy, as one way to allow dynamic exchange of system's characteristics, in order to obtain the lowest power consumption still meeting performance requirements. The basic idea is to have different implementation instances of circuits with the same functionality but with different(More)
ONE OF THE MOST IMPORTANT design issues for mobile multimedia applications such as videophones and video cameras is low energy consumption because of their limited energy budgets or battery capacities. Dynamic voltage scaling (DVS) is a prominent low-power technique for such microprocessor-based systems. 1 It reduces a system's total energy consumption by(More)
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