H.W. de Valk

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The determinants of cerebral complications of type 2 diabetes are unclear. The present study aimed to identify metabolic and vascular factors that are associated with impaired cognitive performance and abnormalities on brain MRI in patients with type 2 diabetes. The study included 122 patients and 56 controls. Neuropsychological test scores were divided(More)
S aquinavir is an antiviral agent FDA-approved for the treatment of HIV. It inhibits HIV protease, a crucial enzyme for the HIV life cycle that cleaves viral polypeptides into essential proteins. When used in combination with nucleo-side analog reverse-transcriptase in-hibitors, protease inhibitors are highly effective in reducing HIV viral loads (1,2). In(More)
UNLABELLED Patients with long-chain fatty acid oxidation defect (LCFAOD) cannot tolerate fasting and are restricted in their physical activity, hence their increased risk of obesity. Experts therefore advise avoidance of catabolic situations and discourage weight reduction in these patients.Two patients with late-diagnosed LCFAOD undergoing treatment at two(More)
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