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Tissue puncture techniques using microelectrodes for various measurements have been criticized for producing undetermined degrees of tissue damage. Therefore, a method permitting routine identification of puncture tracks was developed to determine local microelectrode-induced injury. Rabbits were anesthetized and the femoral arteries surgically exposed. A(More)
A knowledge of the distribution of oxygen tension (PO2) and vascularization in neoplasia has been fundamental to understanding relationships between tumor growth, hypoxia, and therapy. We have combined recessed oxygen microcathode and freeze-substitution techniques to correlate in situ PO2 profiles and morphologic features in 7,12-dimethylbenz(a)anthracene(More)
Bioconcentration of [14C]benzo[a]pyrene and effects of unlabeled benzo[a]pyrene (BaP) accumulation on the routine oxygen consumption of embryonic grunion (Leuresthes tenuis) were studied. At Day 15, bioconcentration factors over dissolved BaP levels ranged from 249 to 466. Weight-specific respiration rates at Days 14-15 were significantly increased (P less(More)