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We have expressed the cloned rat kappa-opioid receptor in human embryonic kidney 293 cells and studied the ability of kappa-selective ligands to inhibit adenylyl cyclase. In transfected 293 cells, activation of the kappa-opioid receptor by U50,488 and the dynorphins resulted in the inhibition of cAMP accumulation. The inhibitory response was sensitive to(More)
In neutrophils, activation of receptors for the chemotactic peptide N-formylmethionyl-leucyl-phenylalanine (fMLP) leads to changes in intracellular events such as phosphoinositide turnover and Ca2+ mobilization. Studies have shown that activation of the cloned fMLP receptor can also lead to inhibition of cyclic AMP (cAMP) accumulation [Lang, Boulay, Li and(More)
OBJECTIVE To detect the expression of angiotensin II type 1 receptor (AT1R) in the different stages of human liver fibrosis. METHODS The morphology and ultrastructure of hepatic stellate cells (HSC) in hepatic sinusoids were studied by transmission electron microscopy, collagen I (col I) was tested by immunohistochemical method, an indirect(More)
In this study, near-field electrospinning (NFES) was used to fabricate PVDF (Polyvinylidene fluoride) piezoelectric nano-fibers mixed with additional multiwalledcarbon nanotubes (MWCNT). Both mechanical strength and piezoelectric characteristics of a single nano-fiber were discussed. NFES technology can be used to fabricate PVDF piezoelectric fibers with an(More)
The performance of leucocyte analysis on the Coulter STKS (Coulter, Hialeah, FL, USA) was evaluated for accuracy, precision and reliability. The results were compared with those obtained from visual examination of a Romanowsky stained blood film together with the automated WBC-diff. from the Technicon H*1 (Technicon, Tarrytown, NY, USA). The relationship(More)
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