H W Honegger

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Bursicon, the insect cuticle-hardening hormone, is a heterodimeric cystine knot protein that activates G protein-coupled receptor LGR2.

C K Luo, Elizabeth M. Dewey, +4 authors Aaron J Hsueh
Proceedings of the National Academy of Sciences…
2005

All arthropods periodically molt to replace their exoskeleton (cuticle). Immediately after shedding the old cuticle, the neurohormone bursicon causes the hardening and darkening of the new cuticle.… (More)

Bursicon, the tanning hormone of insects: recent advances following the discovery of its molecular identity

H W Honegger, Elizabeth M. Dewey, John Ewer
Journal of Comparative Physiology A
2008

Bursicon was identified in 1965 as a peptide neurohormone that initiates the tanning of the insect cuticle immediately after the shedding of the old one during the final stages of the molting… (More)

Bursicon functions within the Drosophila CNS to modulate wing expansion behavior, hormone secretion, and cell death.

Nathan C. Peabody, Fengqiu Diao, +4 authors Benjamin H White
The Journal of neuroscience : the official…
2008

Hormones are often responsible for synchronizing somatic physiological changes with changes in behavior. Ecdysis (i.e., the shedding of the exoskeleton) in insects has served as a useful model for… (More)

Cardioacceleratory function of the neurohormone CCAP in the mosquito Anopheles gambiae.

Tania Y. Estévez-Lao, Dacia S Boyce, H W Honegger, Julián F Hillyer
The Journal of experimental biology
2013

Crustacean cardioactive peptide (CCAP) is a highly conserved arthropod neurohormone that is involved in ecdysis, hormone release and the modulation of muscle contractions. Here, we determined the… (More)

Identification of the Gene Encoding Bursicon, an Insect Neuropeptide Responsible for Cuticle Sclerotization and Wing Spreading

Elizabeth M. Dewey, Susan L McNabb, +4 authors H W Honegger
Current Biology
2004

To accommodate growth, insects must periodically replace their exoskeletons. After shedding the old cuticle, the new soft cuticle must sclerotize. Sclerotization has long been known to be controlled… (More)

Cellular localization of bursicon using antisera against partial peptide sequences of this insect cuticle-sclerotizing neurohormone.

H W Honegger, Daniel Market, +6 authors Karen A Mesce
The Journal of comparative neurology
2002

Bursicon is the final neurohormone released at the end of the molting cycle. It triggers the sclerotization (tanning) of the insect cuticle. Until now, its existence has been verified only by… (More)

Identification, developmental expression, and functions of bursicon in the tobacco hawkmoth, Manduca sexta.

Li Dai, Elizabeth M. Dewey, Dus̆an Z̆itn̆an, C K Luo, H W Honegger, Michael E Adams
The Journal of comparative neurology
2008

During posteclosion, insects undergo sequential processes of wing expansion and cuticle tanning. Bursicon, a highly conserved neurohormone implicated in regulation of these processes, was… (More)

The bursicon gene in mosquitoes: an unusual example of mRNA trans-splicing.

Hugh M. Robertson, Julia A Navik, Kimberly K. O. Walden, H W Honegger
Genetics
2007

The bursicon gene in Anopheles gambiae is encoded by two loci. Burs124 on chromosome arm 2L contains exons 1, 2, and 4, while burs3 on arm 2R contains exon 3. Exon 3 is efficiently spliced into… (More)

Copper/zinc superoxide dismutase-like immunoreactivity in the metamorphosing brain of the sphinx moth Manduca sexta.

Joachim Schachtner, Wolf Huetteroth, Alan Nighorn, H W Honegger
The Journal of comparative neurology
2004

Cu/Zn superoxide dismutase (SOD) is part of the defense mechanism that protects cells from being damaged by reactive oxygen species. During metamorphosis of the nervous system, neurons undergo… (More)

Two peptide transmitters co-packaged in a single neurosecretory vesicle

Elvin A. Woodruff, Kendal Broadie, H W Honegger
Peptides
2008

Numerous neurosecretory cells are known to secrete more than one peptide, in both vertebrates and invertebrates. These co-expressed neuropeptides often originate from differential cleavage of a… (More)

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