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Infantile neuronal ceroid lipofuscinosis (INCL) is a pediatric neurodegenerative disease caused by mutations in the human CLN1 gene. CLN1 encodes palmitoyl-protein thioesterase 1 (PPT1), suggesting an important role for the regulation of palmitoylation in normal neuronal function. To further elucidate Ppt1 function, we performed a gain-of-function modifier(More)
Palmitoylation is the post-translational addition of a palmitate moiety to a cysteine residue through a covalent thioester bond. The addition and removal of this modification is controlled by both palmitoyl acyl-transferases and thioesterases. Using bioinformatic analysis, we identified 22 DHHC family palmitoyl acyl-transferase homologs in the Drosophila(More)
Traditional dependency theory is too difficult, sometimes even for theoreticians (we continue to take notice of articles that describe corrections to published norrnalisation algorithms). Textbooks for beginners often fail to distinguish sharply between a syntactical side (world of "time independent" functional dependencies and normalisation algorithms) and(More)
BACKGROUND Poly-N-acetyl glucosamine nanofibers derived from a marine diatom have been used to increase cutaneous wound healing. These nanofibers exert their activity by specifically activating integrins, which makes them a useful tool for dissecting integrin-mediated pathways. We have shown that short-fiber poly-N-acetyl glucosamine nanofiber (sNAG)(More)
Infantile-onset Neuronal Ceroid Lipofuscinosis (INCL) is a severe pediatric neurodegenerative disorder produced by mutations in the gene encoding palmitoyl-protein thioesterase 1 (Ppt1). This enzyme is responsible for the removal of a palmitate post-translational modification from an unknown set of substrate proteins. To better understand the function of(More)
The notation is as standard as possible. In the schema < U,Dep > , Dep is always a set of dependencies that apply to the set U of attributes (functional dependencies, FD's, multivalued dependencies, MVD's, and join dependencies, JD's). < U,Dep > I = c for a constraint c means that in all relations r for the schema (in which all dependencies of Dep are(More)
I n h i s book (1) on t h e r e l a t i o n a l model v e r s i o n 2 , Codd d e f i n e s a a v a l u e d p r o p o s i t i o n a l l o g i c w i t h two d i f f e r e n t v a l u a t i o n s f o r m is s i n g i n f o r m a t i o n , a i s s i n g a n d a p p l i c a b l e ~ and m i s s i n g a n d i r m p p l i c a b l e . The t r u t h t a b l e s a r e(More)
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