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Caspase-3 is an effector of apoptosis in experimental models of Parkinson's disease (PD). However, its potential role in the human pathology remains to be demonstrated. Using caspase-3 immunohistochemistry on the postmortem human brain, we observed a positive correlation between the degree of neuronal loss in dopaminergic (DA) cell groups affected in the(More)
In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) models of Parkinson's disease (PD), dopaminergic (DA) neurons have been shown to die by apoptosis. Moreover, recent postmortem and in vitro results have indicated that apoptotic cell death induced by 1-methyl-4-phenylpyridinium (MPP(+)) may be mediated by caspase-3. To establish whether caspase-3(More)
Sirs: Leber’s hereditary optic neuropathy (LHON) is a genetic disease due to mutations in mitochondrial DNA (mtDNA) responsible for central, bilateral, painless, and fast progressive visual loss with optic nerve atrophy. Various extra-ocular manifestations, called Leber’s “plus” syndrome, have been described [4]. They include a multiple sclerosis-like(More)
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